2. Anti-infection
  3. Bacterial Antibiotic
  4. Orbifloxacin

オルビフロキサシン  (Synonyms: Orbifloxacin; CP-104354)

製品番号: HY-B0915 純度: 99.66%
COA 取扱説明書 Technical Support

Orbifloxacin is an orally administrable Antibiotic. Orbifloxacin disrupts the replication and proliferation of Bacterial DNA, inhibits bacterial growth and exerts bactericidal activity. Orbifloxacin inhibits the growth of canine-derived E. coli and Pseudomonas aeruginosa isolates. Orbifloxacin is used in research related to bacterial infections.

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Orbifloxacin

オルビフロキサシン 構造式

CAS 番号 : 113617-63-3

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
50 mg $25 在庫あり
100 mg $40 在庫あり
200 mg $64 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Orbifloxacin:

オルビフロキサシン 関連抗体

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Antibiotic アイソフォーム固有の製品をすべて表示:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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製品説明

Orbifloxacin is an orally administrable Antibiotic. Orbifloxacin disrupts the replication and proliferation of Bacterial DNA, inhibits bacterial growth and exerts bactericidal activity. Orbifloxacin inhibits the growth of canine-derived E. coli and Pseudomonas aeruginosa isolates. Orbifloxacin is used in research related to bacterial infections[1][2][3][4].

IC50 & Target

Quinolone

 

体外実験

Orbifloxacin (0.015-4.0 μg/mL; up to 7 days) inhibits the growth of Piscirickettsia salmonis LF-89 VR-1361, and its growth-inhibitory effect persists throughout the 7-day incubation period compared with the untreated control group[1].
Orbifloxacin (0.1×-4× MIC; 0-24 h) inhibits the growth of Staphylococcus aureus ATCC 29213 and ATCC 43300, with MIC values of 0.5 mg/L and 4 mg/L, respectively, and induces concentration-dependent post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PA-SME)[2].
Orbifloxacin (at twice the MIC; 1 h) induces a post-antibiotic effect (PAE) with an average duration of 0.29 h in clinical canine isolates of E coli, and an average PAE duration of 0.37 h in clinical canine isolates of Pseudomonas aeruginosa[3].
Orbifloxacin (0.1×MIC-0.3×MIC) induces concentration-dependent PA-SMEs in canine clinical isolates of E coli (mean 0.55 to 2.03 h) and Pseudomonas aeruginosa (mean 1.04 to 2.47 h)[3].
Orbifloxacin (0.016-16 mg/L; 18 h) inhibits visible growth of clinical Staphylococcus intermedius strains isolated from canine skin and ear infections by 50% and 90% at concentrations of 0.5 mg/L and 1 mg/L, respectively[4].
Orbifloxacin (0.063-4 mg/L; 1-24 h) exhibits concentration-dependent bactericidal activity against Staphylococcus aureus ATCC 29213, and time-dependent bactericidal activity against Staphylococcus intermedius isolates from pyoderma[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

オルビフロキサシン 関連抗体
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-last AUC0-∞ Vd/F CL/F MRT0-last F Vd CL
Mice[2] 2.5 mg/kg i.v. 1.09 h 0.08 h 1.96 mg/L 1.72 μg·h/mL 1.74 μg·h/mL / / 1 h / 2.28 L/kg 1.47 L/h/kg
Mice[2] 5 mg/kg i.v. 1.12 h 0.08 h 3.78 mg/L 4.78 μg·h/mL 4.86 μg·h/mL / / 1.29 h / 1.67 L/kg 1.04 L/h/kg
Mice[2] 20 mg/kg i.v. 2.08 h 0.08 h 8.84 mg/L 17.06 μg·h/mL 17.09 μg·h/mL / / 1.84 h / 3.64 L/kg 1.20 L/h/kg
Mice[2] 80 mg/kg i.v. 1.95 h 0.19 h 21.8 mg/L 54.94 μg·h/mL 54.98 μg·h/mL / / 3.17 h / 4.18 L/kg 1.48 L/h/kg
Mice[2] 2.5 mg/kg i.m. 1.36 h 0.25 h 1.45 mg/L 1.73 μg·h/mL 1.77 μg·h/mL 2.96 L/kg 1.47 L/h/kg 1.14 h 99.9 % / /
Mice[2] 5 mg/kg i.m. 1.42 h 0.22 h 4.18 mg/L 5.12 μg·h/mL 5.15 μg·h/mL 2.00 L/kg 0.98 L/h/kg 1.31 h 107.5 % / /
Mice[2] 20 mg/kg i.m. 2.24 h 0.25 h 9.03 mg/L 18.80 μg·h/mL 18.85 μg·h/mL 3.60 L/kg 1.14 L/h/kg 1.94 h 109.2 % / /
Mice[2] 80 mg/kg i.m. 2.02 h 0.25 h 27.13 mg/L 53.94 μg·h/mL 53.98 μg·h/mL 4.43 L/kg 1.52 1.74 h 98.2 % / /
体内実験

Orbifloxacin (2.5-80 mg/kg; i.m.; twice daily; 24 hours) has an AUC24h/MIC ratio (R2 > 0.98) that is a strong predictor of its in vivo antibacterial efficacy against S. aureus, with targets of 33.78-37.79 h for bacteriostatic activity and 179.43-217.47 h for 3-log10 bacterial kill[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (specific-pathogen-free, 6 weeks old, both sexes, 18 to 20 g, neutropenic thigh infection model induced via intraperitoneal cyclophosphamide)[2]
Dosage: 2.5 mg/kg ; 5 mg/kg ); 20 mg/kg; 80 mg/kg
Administration: i.m.; twice daily; 24 hours
Result: Partially inhibited bacterial growth over 24 hours at total daily doses of 5 and 10 mg/kg.
Inhibited bacterial replication at a total daily dose of 40 mg/kg.
Reduced the bacterial load in the thigh by a maximum of 3.12 log10 over 24 hours at a maximum total daily dose of 160 mg/kg.
分子量

395.38

分子式

C19H20F3N3O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2CC2)C3=C(C(F)=C(F)C(N4C[C@H](C)N[C@H](C)C4)=C3F)C1=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 6 mg/mL (15.18 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5292 mL 12.6461 mL 25.2921 mL
5 mM 0.5058 mL 2.5292 mL 5.0584 mL
10 mM 0.2529 mL 1.2646 mL 2.5292 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5292 mL 12.6461 mL 25.2921 mL 63.2303 mL
5 mM 0.5058 mL 2.5292 mL 5.0584 mL 12.6461 mL
10 mM 0.2529 mL 1.2646 mL 2.5292 mL 6.3230 mL
15 mM 0.1686 mL 0.8431 mL 1.6861 mL 4.2154 mL
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Orbifloxacin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orbifloxacin113617-63-3CP-104354CP104354CP 104354BacterialAntibioticPiscirickettsia salmonisStaphylococcus aureusE coliStaphylococcus intermediusbacterial infections
Inhibitorinhibitorinhibit

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