2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS02160
    CCR5 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR5 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR5 Human Pre-designed siRNA Set A
  • HY-RS02167
    Ccr7 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr7 Mouse Pre-designed siRNA Set A
  • HY-111321
    Fuscin
    		Inhibitor
    Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor.
    Fuscin
  • HY-RS02152
    Ccr2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr2 Mouse Pre-designed siRNA Set A
  • HY-N17908
    Viscumneoside V
    		Inhibitor 98.24%
    Viscumneoside V is a plant-derived anti-inflammatory agent present in Viscum album var. coloratum. Viscumneoside V inhibits the expression of MCP-1 and promotes the production of RANTES in LPS-stimulated immune cells. Viscumneoside V can be used for research related to skin rashes.
    Viscumneoside V
  • HY-P991168
    Velaprumig
    		Inhibitor
    Velaprumig is a monoclonal antibody targeting human CD99, CCL25, and anti-human Aβ (Aβ-47F). Velaprumig regulates immune cell migration and reduces β-amyloid-related pathological processes, exerting immunomodulatory and potential anti - Alzheimer's disease activities.
    Velaprumig
  • HY-RS02153
    Ccr2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Ccr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr2 Rat Pre-designed siRNA Set A
  • HY-RS02157
    CCR4 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR4 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR4 Human Pre-designed siRNA Set A
  • HY-P991135A
    Enzelkitug (FUT8-KO)
    		Inhibitor
    Enzelkitug (RO-7502175; RG-6411) (FUT8-KO) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody. Enzelkitug (FUT8-KO) can be used for the research of various solid tumors and hematological malignancies.
    Enzelkitug (FUT8-KO)
  • HY-136788A
    ALK4290 dihydrochloride
    		Inhibitor
    ALK4290 dihydrochloride (AKST4290 dihydrochlorid) is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism.
    ALK4290 dihydrochloride
  • HY-182439
    AZD3778
    		Inhibitor
    AZD3778 (Compound 8) is an inhibitor of CCR3 and histamine H1 receptor (histamine H1 receptor), with IC50 values of 8.1 nM and 40 nM, respectively. AZD3778 inhibits the binding of eosinophil chemokines to CCR3, as well as the binding of histamine to histamine H1 receptor. AZD3778 exhibits anti-eosinophilic activity. AZD3778 alleviates symptoms associated with allergic rhinitis. AZD3778 can be used in research related to allergic rhinitis and asthma.
    AZD3778
  • HY-119050
    Anti-inflammatory agent 87
    		Inhibitor
    Anti-inflammatory agent 87 (compound 72) is a potential anti-inflammatory agent, whose precursor is an inhibitor targeting the binding of thymus and activation-regulated chemokine (TARC/CCL17) to Hut78 cells. Anti-inflammatory agent 87 can be used in the research of allergic diseases, autoimmune diseases, transplant rejection and other conditions.
    Anti-inflammatory agent 87
  • HY-178926
    RAGE406R
    		Inhibitor
    RAGE406R is an orally active RAGE-DIAPH1 interaction antagonist. RAGE406R can bind to ctRAGE and prevent the formation of the RAGE-DIAPH1 complex and inhibit its interaction. RAGE406R can reduce the expression of CCL2, TNF, and IL-6 in THP1 cells. RAGE406R suppresses delayed-type hypersensitivity in T2D mice. RAGE406R can be used for the study of diabetes.
    RAGE406R
  • HY-P11553
    ECL1i
    		Inhibitor
    ECL1i is an allosteric, selective CCR2 inhibitor. ECL1i specifically inhibits CCL2-/CCR2-mediated chemotaxis. ECL1i interferes with CCR2-positive cell recruitment and attenuates disease progression in experimental autoimmune encephalomyelitis.
    ECL1i
  • HY-RS02154
    CCR3 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR3 Human Pre-designed siRNA Set A
  • HY-P991788
    Anti-Mouse CCR5 Antibody (C5Mab-2)
    		Inhibitor
    Anti-Mouse CCR5 Antibody (C5Mab-2) reacts with mouse CCR5. CCR5 is a seven-pass transmembrane protein from the GPCR family. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CCR5 Antibody (C5Mab-2)
  • HY-176255
    TBK1 degrader-4
    		Inhibitor
    TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD).
    TBK1 degrader-4
  • HY-RS02147
    CCR1 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR1 Human Pre-designed siRNA Set A
  • HY-RS02151
    CCR2 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR2 Human Pre-designed siRNA Set A
  • HY-103406
    PNU-177864
    		Inhibitor
    PNU-177864 is a potent, selective, orally active dopamine D3 receptor antagonist. PNU-177864 induces phospholipid metabolism in vivo and has anti-schizophrenia activity.
    PNU-177864
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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