1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP2 Isoform
  5. CYP2 Inhibitor

CYP2 Inhibitor

CYP2 Inhibitors (42):

Cat. No. Product Name Effect Purity
  • HY-N1201
    Apigenin
    Inhibitor 99.22%
    Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
  • HY-17356
    Fenofibrate
    Inhibitor 99.99%
    Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM.
  • HY-N0319
    Salvianolic acid C
    Inhibitor 99.94%
    Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively.
  • HY-B0876
    Fomepizole
    Inhibitor 99.67%
    Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor.
  • HY-B0258
    Gemfibrozil
    Inhibitor 99.91%
    Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively.
  • HY-150787
    BMS-986339
    Inhibitor
    BMS-986339 is an orally active, potent FXR agonist.
  • HY-151140
    CYP11B1-IN-2
    Inhibitor
    CYP11B1-IN-2 (compound 7aa) is an orally active, potent and selective CYP11B1 inhibitor, with IC50 values of 9 nM and 25 nM for human CYP11B1 and rat CYP11B1, respectively.
  • HY-152159
    CYP4Z1-IN-1
    Inhibitor
    CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM.
  • HY-N2194
    Bergamottin
    Inhibitor 99.80%
    Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.
  • HY-129993
    Gemfibrozil 1-O-β-glucuronide
    Inhibitor 98.71%
    Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.
  • HY-N0043
    Ginsenoside Rd
    Inhibitor 98.02%
    Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells.
  • HY-131968
    BMS-986202
    Inhibitor 99.46%
    BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 of 0.19 nM and a Ki of 0.02 nM.
  • HY-17459
    Clopidogrel hydrogen sulfate
    Inhibitor 99.75%
    Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots.
  • HY-W008364
    Olivetol
    Inhibitor 99.81%
    Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2.
  • HY-N0692
    Schisandrol B
    Inhibitor 99.57%
    Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects.
  • HY-N0893
    Tetrahydrocurcumin
    Inhibitor 99.43%
    Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin.
  • HY-15565
    APD668
    Inhibitor 99.10%
    APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively.
  • HY-N0598
    Ginsenoside F1
    Inhibitor ≥99.0%
    Ginsenoside F1, an enzymatically modified derivative of Ginsenoside Rg1, demonstrates competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity.
  • HY-W010195
    2,6-Dimethylquinoline
    Inhibitor 98.19%
    2,6-Dimethylquinoline, a nature constituent from the roots of Peucedantu praeruptorum, is a CYP1A2 inhibitor with an IC50 of 3.3 µM.
  • HY-N0688
    Linderane
    Inhibitor 98.86%
    Linderane, isolated from the root of Lindera aggregata, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9).