1. Metabolic Enzyme/Protease
    GPCR/G Protein
  2. Cytochrome P450
    Cannabinoid Receptor

Olivetol 

Cat. No.: HY-W008364
Handling Instructions

Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC50s of 15.3 μM, 7.21 μM and Kis of 2.71 μM, 2.87 μM, respectively.

For research use only. We do not sell to patients.

Olivetol Chemical Structure

Olivetol Chemical Structure

CAS No. : 500-66-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • References

Description

Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2[3]. Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC50s of 15.3 μM, 7.21 μM and Kis of 2.71 μM, 2.87 μM, respectively[1][2].

IC50 & Target

IC50: 7.21 μM (CYP2D6)[2], 15.3 μM (CYP2C19)[1]
Ki: 2.71 μM (CYP2C19)[1], 2.87 μM (CYP2D6)[2]
CB1, CB2[3]

In Vitro

Olivetol inhibits the (S)-mephenytoin 4'-hydroxylase activity of CYP2C19 activity with an IC50 of 15.3 μM and a Ki of 2.71 μM[1]. Olivetol also inhibits AMMC O-demethylase activity of recombinant CYP2D6 with an IC50 of 7.21 μM and a Ki of 2.87 μM[2].
Olivetol is a competitive inhibitor of the cannabinoid receptors CB1 and CB2[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5482 mL 27.7408 mL 55.4816 mL
5 mM 1.1096 mL 5.5482 mL 11.0963 mL
10 mM 0.5548 mL 2.7741 mL 5.5482 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

180.24

Formula

C₁₁H₁₆O₂

CAS No.

500-66-3

SMILES

OC1=CC(CCCCC)=CC(O)=C1

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Olivetol
Cat. No.:
HY-W008364
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Olivetol

Cat. No.: HY-W008364