2. Metabolic Enzyme/Protease
  3. β-glucuronidase Cytochrome P450
  4. Saccharolactone

Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM).

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Saccharolactone

Saccharolactone Chemical Structure

CAS No. : 389-36-6

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Saccharolactone Related Antibodies

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View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM)[1][2][3].

IC50 & Target[1][2][3]

CYP1A2

<4 mM (IC50)

CYP2D6

<4 mM (IC50)

CYP3A4

<4 mM (IC50)

CYP2C8

<4 mM (IC50)

Molecular Weight

192.12

Formula

C6H8O7
CAS No.
SMILES

OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Saccharolactone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saccharolactone389-36-6β-glucuronidaseCytochrome P450GUSBCYPsrat bilestabilize glucuronide metabolitesInhibitorinhibitorinhibit

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