389-36-6
389-36-6
Chemical Structure
Saccharolactone
- CAS No.: 389-36-6
- Formula:C6H8O7
- Molecular Weight:192.12
InChIKey: XECPAIJNBXCOBO-MMPJQOAZSA-N
SMILES: OC([C@H]([C@]1([H])[C@@H]([C@H](C(O1)=O)O)O)O)=O
Biological Activity: Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Saccharolactone | Saccharolactone is a potent orally active β-glucuronidase inhibitor. Saccharolactone markedly lowers biliary endogenous β-glucuronidase activity in the rat bile. Saccharolactone can stabilize glucuronide metabolites in vitro. Saccharolactone is also a strong inhibitor of CYP1A2, 2D6, 3A4 and 2C8 isoforms (IC50 < 4 mM). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Macfadyen A, et al. D-glucaro-1,4-lactone: its excretion in the bile and urine and effect on the biliary secretion of beta-glucuronidase after oral administration in rats. Hepatology. 1989 Apr;9(4):552-6. [Content Brief]
- [2]. Behera D, et al. Effect of Saccharolactone on CYP-mediated Metabolism of Xenobiotics. Drug Metab Bioanal Lett. 2023;16(2):121-132. [Content Brief]
- [3]. Oleson L, et al. Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases. J Pharm Pharmacol. 2008 Sep;60(9):1175-82. [Content Brief]
Keywords
