2. シグナル伝達
  3. Metabolic Enzyme/Protease
  4. Phosphatase

Phosphatase

Phosphatase

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Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.

製品番号 製品名 製品効果 純度 構造式
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    ZLDI-8 Inhibitor 98.47%
    ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM.
    ZLDI-8
  • HY-13756R
    Tacrolimus (Standard) Inhibitor
    Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
    Tacrolimus (Standard)
  • HY-137092
    IACS-13909 Inhibitor 99.97%
    IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers.
    IACS-13909
  • HY-131132
    JAB-3068 Inhibitor 99.44%
    JAB-3068 (SHP2-IN-6) is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM.
    JAB-3068
  • HY-101510
    F1063-0967 Inhibitor 99.30%
    F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
    F1063-0967
  • HY-15880
    CCT007093

    CCT007093

    		Inhibitor 98.34%
    CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy.
    CCT007093
  • HY-10704
    PTP1B-IN-1 Inhibitor 99.71%
    PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues.
    PTP1B-IN-1
  • HY-109589A
    trans-11-Eicosenoic acid Inhibitor 99.95%
    trans-11-Eicosenoic acid is a fatty acid that inhibits the phosphatase activity of PtpA from Mycobacterium tuberculosis, with an IC50 of 27.97 µM. trans-11-Eicosenoic acid is detected in the stems of alfalfa plants inoculated with Sinorhizobium meliloti LL11, but is absent in the stems of uninoculated alfalfa or the strain itself.
    trans-11-Eicosenoic acid
  • HY-155374
    PP5-IN-1 Inhibitor 99.47%
    PP5-IN-1 is a competitive and selective serine/threonine protein phosphatase 5 (PP5) inhibitor with a Ki value of 244 nM. PP5-IN-1 induces extrinsic apoptosis (Apoptosis), disrupts the integrity of complex II, and activates Caspase 8. PP5-IN-1 can be used in research related to clear cell renal cell carcinoma.
    PP5-IN-1
  • HY-112776A
    BN82002 hydrochloride Inhibitor 99.36%
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    BN82002 hydrochloride
  • HY-12312
    TCS 401 Inhibitor 98.0%
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401
  • HY-170404
    KF-52 Inhibitor 98.94%
    KF-52 is a phosphofructokinase-1 (PFK1) inhibitor with an IC50 value of 2.1 μM. KF-52 significantly increases the ratio of oxygen consumption rate (OCR) to extracellular acidification rate (ECAR). KF-52 is applicable to research related to mitochondrial dysfunction.
    KF-52
  • HY-15133
    PTP1B-IN-3 Inhibitor 99.69%
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    PTP1B-IN-3
  • HY-124366
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    Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2.
    Slingshot inhibitor D3
  • HY-19383
    Ertiprotafib Inhibitor 98.13%
    Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
    Ertiprotafib
  • HY-N1941
    Isosinensetin Inhibitor 99.90%
    Isosinensetin is a flavonoid compound and an inhibitor of HIV-1 protease and PTP1B (IC50: 2.61 µM; Ki: 0.92 µM). Isosinensetin inhibits P-glycoprotein (P-gp) in MDR1-MDCKII cells. Isosinensetin has multiple activities such as anti-tumor, anti-viral, anti-inflammatory, and antioxidant effects. Isosinensetin can be used in the research of various diseases including cancer, inflammation, osteoporosis, diabetes, etc.
    Isosinensetin
  • HY-123960A
    Raphin1 acetate Inhibitor 99.93%
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    Raphin1 acetate
  • HY-14210
    TNAP-IN-1 Inhibitor 98.56%
    TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC50 of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification.
    TNAP-IN-1
  • HY-141800
    MurA-IN-1 Inhibitor 99.32%
    MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively. (A family of human MAPK-specific protein tyrosine phosphatases)
    MurA-IN-1
  • HY-160791A
    Claramine TFA Inhibitor
    Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
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製品番号 製品名 / Synonyms Application Reactivity