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Slingshot inhibitor D3 

Cat. No.: HY-124366
Handling Instructions

Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2.

For research use only. We do not sell to patients.

Slingshot inhibitor D3 Chemical Structure

Slingshot inhibitor D3 Chemical Structure

CAS No. : 1715076-35-9

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Based on 1 publication(s) in Google Scholar

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Description

Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2[1].

IC50 & Target

Ki: 3.9 μM (Slingshot 2)[1].
IC50: 3 μM (Slingshot 1)[1]

In Vitro

Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes[1].
Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation[1].
Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 5 μM
Incubation Time: 45 minutes
Result: Significantly blocked NGF-induced dephosphorylation of cofilin at 15 and 30 minutes.
Molecular Weight

461.55

Formula

C₂₅H₁₉NO₄S₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (54.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1666 mL 10.8331 mL 21.6661 mL
5 mM 0.4333 mL 2.1666 mL 4.3332 mL
10 mM 0.2167 mL 1.0833 mL 2.1666 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
Slingshot inhibitor D3
Cat. No.:
HY-124366
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