Slingshot inhibitor D3
Based on 1 Customer Validation
Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2.
For research use only. We do not sell to patients.
- Purity: 99.46%
- CAS No.: 1715076-35-9
- Formula: C25H19NO4S2
- Molecular Weight:461.55
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes[1].
Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation[1].
Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:5 μM
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Incubation Time:45 minutes
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Result:Significantly blocked NGF-induced dephosphorylation of cofilin at 15 and 30 minutes.
Chemical Information
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CAS No. 1715076-35-9
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Appearance Solid
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Molecular Weight 461.55
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Formula C25H19NO4S2
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C(C3=O)\SC(N3C4=CC=CC=C4C)=S)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (54.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1666 mL | 10.8331 mL | 21.6661 mL | 54.1653 mL |
| 5 mM | 0.4333 mL | 2.1666 mL | 4.3332 mL | 10.8331 mL | |
| 10 mM | 0.2167 mL | 1.0833 mL | 2.1666 mL | 5.4165 mL | |
| 15 mM | 0.1444 mL | 0.7222 mL | 1.4444 mL | 3.6110 mL | |
| 20 mM | 0.1083 mL | 0.5417 mL | 1.0833 mL | 2.7083 mL | |
| 25 mM | 0.0867 mL | 0.4333 mL | 0.8666 mL | 2.1666 mL | |
| 30 mM | 0.0722 mL | 0.3611 mL | 0.7222 mL | 1.8055 mL | |
| 40 mM | 0.0542 mL | 0.2708 mL | 0.5417 mL | 1.3541 mL | |
| 50 mM | 0.0433 mL | 0.2167 mL | 0.4333 mL | 1.0833 mL |
Slingshot inhibitor D3 Related Classifications
HY-124366 Related Classifications
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