Claramine TFA 

Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins^[1].

Claramine (2-20 μM; 20 h) does not affect cell viability in human neuroblastoma cells (SH-SY5Y) at concentrations below 10 μM. Similarly, Claramine (2-20 μM; 20 h) does not impact cell activity in HEK293 cells^[1].
Claramine (2.5-10 μM; 20 h) protects human neuroblastoma (SH-SY5Y) cells from the harmful effects of pore-forming agents, melittin (HY-P0233) (4 μM; 20 h) and α-hemolysin (50 μg/mL; 20 h), by inhibiting their binding to cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

703.02

C₃₉H₇₃F₃N₄O₃

3030428-57-7

C[C@@]12[C@]3([H])[C@](C[C@H](C1([H])C[C@H](CC2)O)NCCCNCCCCNCCCN)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kreiser RP, et al. A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents. ACS Chem Neurosci. 2022;13(8):1219-1231.  [Content Brief]