Virus Protease

Related Products

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Virus Protease Inhibitors (148)

Virus Protease Related Products (158)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N0469

L-Lysine	Inhibitor	≥98.0%
L-lysine is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions.

HY-13949

SRPIN340	Inhibitor	99.97%
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a K_i of 0.89 μM for SRPK1.

HY-N0110

Palmatine chloride	Inhibitor	99.77%
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

HY-N0002

(-)-Epicatechin gallate	Inhibitor	98.57%
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

HY-100576

NH125	Inhibitor	99.81%
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII), also can induce eEF2 phosphorylation, with an IC₅₀ of 60 nM for eEF-2K.

HY-B0388

Probucol	Inhibitor	99.97%
Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-B0448

Phenytoin	Inhibitor	99.91%
Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.

HY-139602

(+)-JNJ-A07	Inhibitor	≥98.0%
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models.

HY-106161

Rupintrivir	Inhibitor	99.91%
Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect.

HY-N0289

Lycorine hydrochloride	Inhibitor	99.89%
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC₅₀ of 1.2 μM).

HY-12046

PIK-93	Inhibitor	99.81%
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC₅₀ of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC₅₀ of 16 nM and 39 nM, respectively.

HY-B0182

Carmofur	Inhibitor	99.95%
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).

HY-N0017

Bergenin	Inhibitor	99.21%
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties.

HY-143216A

Ensitrelvir fumarate	Inhibitor	99.99%
Ensitrelvir (S-217622) fumarate is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC₅₀=13 nM).

HY-B0923

Danthron	Inhibitor	99.19%
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

HY-19711

STING agonist-1	Inhibitor	99.56%
STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC₉₀ of 24.57 μM.

HY-B0448A

Phenytoin sodium	Inhibitor	99.84%
Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na⁺ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.

HY-136465

A2ti-1	Inhibitor	99.84%
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC₅₀ of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection.

HY-N0184A

Dipotassium glycyrrhizinate	Inhibitor	99.51%
Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity.

HY-N0731

Genkwanin	Inhibitor	99.82%
Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.

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Virus Protease

Virus Protease

Virus Protease Related Products (158)

Antibodies (1)

Virus Protease Related Products (158):