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Phenytoin sodium (Synonyms: 5,5-Diphenylhydantoin sodium salt)

Cat. No.: HY-B0448A Purity: 99.96%
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Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.

For research use only. We do not sell to patients.

Phenytoin sodium Chemical Structure

Phenytoin sodium Chemical Structure

CAS No. : 630-93-3

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Description

Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

In Vitro

Phenytoin sodium is an antiepileptic drug. It is useful to treat partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels[2].
Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials[3].
When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin is a class 1b antiarrhythmic[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phenytoin sodium (5,5-Diphenylhydantoin sodium salt; 60 mg/kg; daily; 28 days ) reduces tumour growth in six week-old female Rag2-/- Il2rg-/- mice with MDA-MB-231 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

274.25

Formula

C₁₅H₁₁N₂NaO₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (182.32 mM; Need ultrasonic)

H2O : 1 mg/mL (3.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6463 mL 18.2315 mL 36.4631 mL
5 mM 0.7293 mL 3.6463 mL 7.2926 mL
10 mM 0.3646 mL 1.8232 mL 3.6463 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Phenytoin sodium
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