Lycorine hydrochloride
Based on 24 publication(s) in Google Scholar
Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 2188-68-3
- Formula: C16H18ClNO4
- Molecular Weight:323.77
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
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Publications Citing Use of MedChemExpress (MCE) Lycorine hydrochloride
More- J Nanobiotechnology. 2026 Mar 22;24(1):405. [Abstract]
- J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
- Pharmacol Res. 2022 Jan:175:105985. [Abstract]
- Int J Mol Med. 2022 Dec;50(6):145. [Abstract]
- Eur J Pharmacol. 2023 Dec 15:961:176162. [Abstract]
- Int J Mol Sci. 2025 Jun 3;26(11):5358. [Abstract]
- Mol Med Rep. 2024 Mar;29(3):48. [Abstract]
- J Mol Cell Cardiol. 2026 Apr 28:S0022-2828(26)00059-3. [Abstract]
- Cancers (Basel). 2025 Feb 20;17(5):718. [Abstract]
- Microorganisms. 2022 Oct 21;10(10):2089. [Abstract]
- Antiviral Res. 2024 Jul 2:228:105955. [Abstract]
- Pest Manag Sci. 2026 Jun 20. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- J Nat Med. 2026 Mar 9. [Abstract]
- Ann Hematol. 2026 Jan 17;105(1):24. [Abstract]
- Ann Hematol. 2023 May;102(5):1073-1086. [Abstract]
- Oncol Lett. 2021 Nov;22(5):781. [Abstract]
- Mol Biol. 2026 Jan 20.
- SSRN. 2025 Dec 19.
- Preprints. 2024 Nov.
- bioRxiv. 2024 Feb 6:2024.02.06.579103. [Abstract]
- Patent. US20230014181.
- Research Square Preprint. 2022 Feb.
- Research Square Preprint. 2022 Jan.
Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Flow Cytometry
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In Vivo Efficacy Study
Biological Activity
IC50: 1.2 μM (Hey1B cells )[2]
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected[1].
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C8161 cells
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Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
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Incubation Time:48 hours
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Result:Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.
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Cell Line:C8161 cells
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Concentration:0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
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Incubation Time:48 hours
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Result:Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6- to 8-week-old BALB/C nude mice[1]
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Dosage:0 μg, 7.5 μg, 15 μg
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Administration:Subcutaneous injection; for 14 days
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Result:Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Chemical Information
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CAS No. 2188-68-3
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Appearance Solid
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Molecular Weight 323.77
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Formula C16H18ClNO4
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Color White to off-white
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SMILES
O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (24)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway. [Abstract]2026 Mar 22;24(1):405. PMID: 41866523 -
J Exp Clin Cancer Res
Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. [Abstract]2022 Mar 30;41(1):116. PMID: 35354475
Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Immunoblot analysis of SCAP protein expression at different concentrations. PLC-SR cells (control) were treated with Lycorine (Ly) (1, 2, 4 μM) alone, Sorafenib (Sora) alone or a combination of Lycorine and Sorafenib (Ly + Sora).
Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
The combined use of Lycorine (1, 2, 4 μM) and Sorafenib significantly inhibited the proliferation of PLC-SR cells.
Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Lycorine (1, 2, 4 μM) combined with Sorafenib decelerated the migration and invasion of sorafenib-resistant HCC cells.
Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Flow cytometry analysis indicated that when Lycorine (1, 2, 4 μM) was combined with Sorafenib, the percentage of S phase cells was decreased, and apoptosis was significantly increased.
Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]
Lycorine (10 mg/kg, i.g.) combined with Sorafenib can reduce the tumor volume in mice.
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Pharmacol Res
Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy. [Abstract]2022 Jan:175:105985. PMID: 34863821 -
Int J Mol Med
Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. [Abstract]2022 Dec;50(6):145. PMID: 36367172 -
Eur J Pharmacol
Lycorine eliminates B-cell acute lymphoblastic leukemia cells by targeting PSAT1 through the serine/glycine metabolic pathway. [Abstract]2023 Dec 15:961:176162. PMID: 37951487 -
Int J Mol Sci
Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [Abstract]2025 Jun 3;26(11):5358. PMID: 40508167 -
Mol Med Rep
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway. [Abstract]2024 Mar;29(3):48. PMID: 38275129 -
J Mol Cell Cardiol
Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells. [Abstract]2026 Apr 28:S0022-2828(26)00059-3. PMID: 42061807 -
Cancers (Basel)
Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways. [Abstract]2025 Feb 20;17(5):718. PMID: 40075566 -
Microorganisms
Screening of Endophytic Bacteria of Leucojum aestivum 'Gravety Giant' as a Potential Source of Alkaloids and as Antagonist to Some Plant Fungal Pathogens. [Abstract]2022 Oct 21;10(10):2089. PMID: 36296365 -
Antiviral Res
Discovery of hepatitis B virus subviral particle biogenesis inhibitors from a bioactive compound library. [Abstract]2024 Jul 2:228:105955. PMID: 38964614 -
Pest Manag Sci
Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura. [Abstract]2026 Jun 20. PMID: 42322590 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
J Nat Med
A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis. [Abstract]2026 Mar 9. PMID: 41801295 -
Ann Hematol
Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1. [Abstract]2026 Jan 17;105(1):24. PMID: 41545705 -
Ann Hematol
Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5. [Abstract]2023 May;102(5):1073-1086. PMID: 36943465 -
Oncol Lett
Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells. [Abstract]2021 Nov;22(5):781. PMID: 34594422 -
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bioRxiv
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease. [Abstract]2024 Feb 6:2024.02.06.579103. PMID: 38370689 -
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Solvent & Solubility
DMSO : 25 mg/mL (77.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 16.67 mg/mL (51.49 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (285 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012). [Content Brief]
[2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013). [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0886 mL | 15.4431 mL | 30.8861 mL | 77.2153 mL |
| 5 mM | 0.6177 mL | 3.0886 mL | 6.1772 mL | 15.4431 mL | |
| 10 mM | 0.3089 mL | 1.5443 mL | 3.0886 mL | 7.7215 mL | |
| 15 mM | 0.2059 mL | 1.0295 mL | 2.0591 mL | 5.1477 mL | |
| 20 mM | 0.1544 mL | 0.7722 mL | 1.5443 mL | 3.8608 mL | |
| 25 mM | 0.1235 mL | 0.6177 mL | 1.2354 mL | 3.0886 mL | |
| 30 mM | 0.1030 mL | 0.5148 mL | 1.0295 mL | 2.5738 mL | |
| 40 mM | 0.0772 mL | 0.3861 mL | 0.7722 mL | 1.9304 mL | |
| 50 mM | 0.0618 mL | 0.3089 mL | 0.6177 mL | 1.5443 mL | |
| DMSO | 60 mM | 0.0515 mL | 0.2574 mL | 0.5148 mL | 1.2869 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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