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Lycorine hydrochloride 

Cat. No.: HY-N0289 Purity: 99.89%
Handling Instructions

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radia and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM).

For research use only. We do not sell to patients.

Lycorine hydrochloride Chemical Structure

Lycorine hydrochloride Chemical Structure

CAS No. : 2188-68-3

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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25 mg USD 108 In-stock
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50 mg USD 180 In-stock
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100 mg USD 264 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radia and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2].

IC50 & Target

IC50: 1.2 μM (Hey1B cells )[2]

In Vitro

Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected[1].
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.

Western Blot Analysis[1]

Cell Line: C8161 cells
Concentration: 0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time: 48 hours
Result: Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.
In Vivo

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old BALB/C nude mice[1]
Dosage: 0 μg, 7.5 μg, 15 μg
Administration: Subcutaneous injection; for 14 days
Result: Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.
Molecular Weight

323.77

Formula

C₁₆H₁₈ClNO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (77.22 mM; Need ultrasonic)

H2O : 16.67 mg/mL (51.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0886 mL 15.4431 mL 30.8861 mL
5 mM 0.6177 mL 3.0886 mL 6.1772 mL
10 mM 0.3089 mL 1.5443 mL 3.0886 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Lycorine hydrochloride
Cat. No.:
HY-N0289
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