2. Immunology/Inflammation Anti-infection
  3. STING Virus Protease
  4. STING agonist-1

STING agonist-1  (Synonyms: G10)

Cat. No.: HY-19711 Purity: 99.56%
COA Handling Instructions

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.

For research use only. We do not sell to patients.

STING agonist-1 Chemical Structure

STING agonist-1 Chemical Structure

CAS No. : 702662-50-8

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Solution
10 mM * 1 mL in DMSO USD 99 In-stock
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ready for reconstitution
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10 mg USD 135 In-stock
50 mg USD 565 In-stock
100 mg USD 1050 In-stock
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Based on 2 publication(s) in Google Scholar

STING agonist-1 Related Antibodies

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Description

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].

IC50 & Target

IC90: 24.57 μM (VEEV)[1]
In Vitro

G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].
G10 is an indirect activator of human STING-dependent phenotypes[1].
G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].
STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].
G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].
G10 induces innate antiviral mRNA expression in primary human cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STING agonist-1 Related Antibodies
Clinical Trial
Molecular Weight

430.88

Appearance

Solid

Formula

C21H16ClFN2O3S
CAS No.
SMILES

O=C(C1=CC=C(SCC(N2CC3=C(F)C=CC=C3Cl)=O)C2=C1)NCC4=CC=CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (174.06 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3208 mL 11.6042 mL 23.2083 mL
5 mM 0.4642 mL 2.3208 mL 4.6417 mL
10 mM 0.2321 mL 1.1604 mL 2.3208 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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STING agonist-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

STING agonist-1702662-50-8G10STING agonist1STING agonist 1G 10G-10STINGVirus ProteaseStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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