1. Immunology/Inflammation
    Anti-infection
  2. STING
    Virus Protease
  3. STING agonist-1

STING agonist-1 (Synonyms: G10)

Cat. No.: HY-19711 Purity: 99.93%
Handling Instructions

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM.

For research use only. We do not sell to patients.

STING agonist-1 Chemical Structure

STING agonist-1 Chemical Structure

CAS No. : 702662-50-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 565 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1].

IC50 & Target

IC90: 24.57 μM (VEEV)[1]

In Vitro

G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].
G10 is an indirect activator of human STING-dependent phenotypes[1].
G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].
STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].
G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].
G10 induces innate antiviral mRNA expression in primary human cells[1].

Clinical Trial
Molecular Weight

430.88

Formula

C₂₁H₁₆ClFN₂O₃S

CAS No.

702662-50-8

SMILES

O=C(C1=CC=C(SCC(N2CC3=C(F)C=CC=C3Cl)=O)C2=C1)NCC4=CC=CO4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.08 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3208 mL 11.6042 mL 23.2083 mL
5 mM 0.4642 mL 2.3208 mL 4.6417 mL
10 mM 0.2321 mL 1.1604 mL 2.3208 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.93%

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Keywords:

STING agonist-1G10STING agonist1STING agonist 1G 10G-10STINGVirus ProteaseStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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Product name:
STING agonist-1
Cat. No.:
HY-19711
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