A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis

  • J Nat Med. 2026 Mar 9. doi: 10.1007/s11418-025-01966-8.
Meng Lv  1  2  3 ,  Xiangrui Chen  4 ,  Yaqiong Wang  1  2  3 ,  Qiting Yang  5 ,  Yongbiao Lv  6 ,  Wei Xie  1  2  3 ,  Junxiang Cai  7
Affiliations
  • 1. Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, China.
  • 2. The Fourth Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 3. Shenzhen Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Shenzhen, China.
  • 4. Department of Hematology and Oncology, Third People's Hospital of Zigong, Zigong, China.
  • 5. Department of Cardiopulmonary Rehabilitation and Sleep Medicine, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 6. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 7. Department of Respiratory and Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 111, Dade Road, Guangzhou, 510120, China. [email protected].
PMID: 41801295 DOI: 10.1007/s11418-025-01966-8
Keywords
Lycorine; Non-small cell lung cancer; SPC25; ZNF143.
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