1. Anti-infection
  2. Virus Protease
  3. A2ti-1

A2ti-1 

Cat. No.: HY-136465
Handling Instructions

A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection.

For research use only. We do not sell to patients.

A2ti-1 Chemical Structure

A2ti-1 Chemical Structure

CAS No. : 570390-00-0

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Description

A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection[2].

IC50 & Target

IC50: 24 μM (A2t)[1]

In Vitro

A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker[1].
A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner[2].
A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner[2].

Cell Viability Assay[2]

Cell Line: HeLa cells
Concentration: 100 μM
Incubation Time: For 72 hours
Result: Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells.
Molecular Weight

382.48

Formula

C₂₀H₂₂N₄O₂S

CAS No.

570390-00-0

SMILES

O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3CC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

A2ti-1Virus ProteaseannexinA2S100A10heterotetramerA2tprotein-proteininteractionPPIhumanpapillomavirustype16HPV16HPVInhibitorinhibitorinhibit

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A2ti-1
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