570390-00-0
570390-00-0
Chemical Structure
A2ti-1
- CAS No.: 570390-00-0
- Formula:C20H22N4O2S
- Molecular Weight:382.48
IUPAC Name: 2-((4-(2-ethylphenyl)-5-((o-tolyloxy)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChIKey: KNQGIFUBCFRGDB-UHFFFAOYSA-N
SMILES: O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3CC
Biological Activity: A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A2ti-1 | 99.78% | A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection. | ||||||||||||||||||||
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References
- [1]. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46. [Content Brief]
- [2]. Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70(6):1686-90. [Content Brief]
