2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage GPCR/G Protein
  3. Endogenous Metabolite DNA/RNA Synthesis P2Y Receptor
  4. Uridine triphosphate

Uridine triphosphate  (Synonyms: UTP; Uridine 5'-triphosphate)

製品番号: HY-107372
取扱説明書 Technical Support

Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Uridine triphosphate trisodium salt) that retains the same biological activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Uridine triphosphate

Uridine triphosphate 構造式

CAS 番号 : 63-39-8

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of Uridine triphosphate:

Uridine triphosphate 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Human Endogenous Metabolite Microbial Metabolite

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

P2Y Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
A549 EC50
0.45 3
Compound: UTP
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
[PMID: 16539385]
A549 EC50
0.45 3
Compound: UTP
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
[PMID: 16539385]
A549 EC50
0.45 3
Compound: UTP
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
Activity against human P2Y2-GFP expressed in A549 cells by intracellular calcium increase
[PMID: 16539385]
HEK293 EC50
0.13 3
Compound: UTP
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
[PMID: 16539385]
HEK293 EC50
0.13 3
Compound: UTP
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
[PMID: 16539385]
HEK293 EC50
0.13 3
Compound: UTP
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
Activity against rat P2Y2-GFP transfected in HEK293 cells by intracellular calcium increase
[PMID: 16539385]
NG108-15 EC50
1.26 3
Compound: UTP
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
[PMID: 19523835]
NG108-15 EC50
1.26 3
Compound: UTP
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
[PMID: 19523835]
NG108-15 IC50
1.51 3
Compound: UTP
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
[PMID: 19523835]
NG108-15 IC50
1.51 3
Compound: UTP
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
[PMID: 19523835]
NG108-15 EC50
1.26 3
Compound: UTP
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
Agonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as increase in intracellular calcium release by fluorescence assay
[PMID: 19523835]
NG108-15 IC50
1.51 3
Compound: UTP
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
Antagonist activity at mouse P2Y2 receptor expressed in NG108-15 hybrid cells assessed as inhibition of 1 uM UTP-induced intracellular calcium release preincubated 30 mins before UTP challenge by fluorescence assay
[PMID: 19523835]
体外実験

Uridine triphosphate enhances the migration and wound repair of RT4-D6P2T cells by activating the P2Y2 receptor and increasing the activation and expression of extracellular MMP-2[2].
Uridine triphosphate induces MAPK phosphorylation in a biphasic manner. It causes early transient phosphorylation within 5 minutes after treatment, and late persistent phosphorylation occurs 6 hours later, lasting for up to 24 hours[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine triphosphate 関連抗体

Western Blot Analysis[2]

Cell Line: RT4-D6P2T cells
Concentration: 250 µM
Incubation Time: 5 min, 45 min, 2 h, 6 h, 12 h, 24 h, 48 h
Result: Induces biphasic MAPK phosphorylation.
体内実験

Uridine triphosphate (0.44-4.4 μg/kg; i.v.; once) reduces infarct size and improves rat heart function after myocardial infarct[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-300 g; 2-3 months) with myocardial infarction (MI)[3]
Dosage: 0.44 µg/kg 30 min before MI, and 4.4 µg/kg i.v. 24 h prior to MI.
Administration: i.v.; once
Result: Reduced infarct size and improves rat heart function after myocardial infarct.
分子量

484.14

分子式

C9H15N2O15P3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(OP(OP(O)(O)=O)(O)=O)=O)O2)NC(C=C1)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years

* The compound is unstable in solutions, freshly prepared is recommended.

溶剤 & 溶解度
体外: 

H2O : ≥ 150 mg/mL (309.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0655 mL 10.3276 mL 20.6552 mL
5 mM 0.4131 mL 2.0655 mL 4.1310 mL
10 mM 0.2066 mL 1.0328 mL 2.0655 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (206.55 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.0655 mL 10.3276 mL 20.6552 mL 51.6380 mL
5 mM 0.4131 mL 2.0655 mL 4.1310 mL 10.3276 mL
10 mM 0.2066 mL 1.0328 mL 2.0655 mL 5.1638 mL
15 mM 0.1377 mL 0.6885 mL 1.3770 mL 3.4425 mL
20 mM 0.1033 mL 0.5164 mL 1.0328 mL 2.5819 mL
25 mM 0.0826 mL 0.4131 mL 0.8262 mL 2.0655 mL
30 mM 0.0689 mL 0.3443 mL 0.6885 mL 1.7213 mL
40 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2909 mL
50 mM 0.0413 mL 0.2066 mL 0.4131 mL 1.0328 mL
60 mM 0.0344 mL 0.1721 mL 0.3443 mL 0.8606 mL
80 mM 0.0258 mL 0.1291 mL 0.2582 mL 0.6455 mL
100 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5164 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Uridine triphosphate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine triphosphate63-39-8UTP Uridine 5'-triphosphateEndogenous MetaboliteDNA/RNA SynthesisP2Y ReceptorInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Uridine triphosphate
製品番号:
HY-107372
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.