2. 天然物
  3. Disease Research Fields Plants Endogenous metabolite Quinones
  4. other families Human Gut Microbiota Metabolites Naphthalene Quinones
  5. Vitamin K1

Vitamin K1  (Synonyms: ビタミンK1; フィロキノン; Phylloquinone; Phytomenadione)

製品番号: HY-N0684 純度: 98.60%
COA 取扱説明書 Technical Support

Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 84-80-0

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Liquid
500 mg $30 在庫あり
1 g $45 在庫あり
5 g $125 在庫あり
10 g $220 在庫あり
25 g $350 在庫あり
50 g $520 在庫あり
100 g $730 在庫あり
> 100 g   お問い合わせ  

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カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Vitamin K1:

Vitamin K1 関連抗体

Top Publications Citing Use of Products

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    Cell viability of chondrocytes treated with ferroptosis inducers ((1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1,10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1, 1 μM) for 24 h was detected by Cell Counting Kit-8 (CCK-8).

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    Bright-field and fluorescent images of live/dead staining of chondrocytes treated with ferroptosis inducers (1S,3R)-RSL3 (RSL3; 0.5 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h. Propidium iodide (PI) stained (Red) for dead cells, and Calcein-AM (Green) stained for live cells.

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    The protein levels of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1;10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by Western blotting assay

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    The mRNA levels of catabolic enzymes (Mmp13 and Adamts4) and matrix components (Col2a1 and Acan) in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h were determined by RT-qPCR.

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    Immunofluorescence of MMP13, ADAMTS4, COL II and Aggrecan in chondrocytes treated with ferroptosis inducers erastin (10 μM), vitamin K1 (VK1; 10 μM) and ferroptosis inhibitor Ferrostatin-1 (Fer-1; 1 μM) for 24 h.

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    Representative images of IHC of matrix metalloproteinase 13 (MMP13), collagen type II (COL II), GPX4 and Gas6 in cartilage sections of mice injected intraarticularly with VK1 (1 mg/kg, DMM + VK1 + AAV-NC and DMM + VK1 + AAV-shGas6 groups) or vehicle (Sham + AAV-NC groups) twice a week for two weeks.

    Vitamin K1 purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 May;15(5):101092.

    Representative images of H&E, safranin O fast green and toluidine blue staining of cartilage sections of mice injected intraarticularly with VK1 (1 mg/kg, DMM + VK1 + AAV-NC and DMM + VK1 + AAV-shGas6 groups), Ferrostatin-1 (Fer-1; 0.1 mg/kg, DMM + Fer-1 + AAV-NC group) or vehicle (Sham + AAV-NC and DMM + AAV-NC groups) twice a week for two weeks.

    • 生物活性

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Phylloquinone (Vitamin K1) is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. In humans and other vertebrates, phylloquinone plays the role of a vitamin (vitamin K1) that is required for blood coagulation and bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans[1]. Vitamin K1 treatment causes a significant antiproliferative effect and induces apoptosis in Caco-2, HT-29, and SW480 cell lines, with the involvement of the MAPK pathway. A concomitant and significant decrease in the polyamine biosynthesis occurr[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Vitamin K1 関連抗体
    体内実験

    Subjects who increase their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decrease or does not change the amount of phylloquinone intake[3]. Vitamin K supplementation reverses the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice[4]. Application of vitamin K1 to the skin has been used for suppression of pigmentation and resolution of bruising. The effects produced by the topical vitamin K1 shows significant healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    450.70

    分子式

    C31H46O2
    CAS 番号
    Appearance

    Liquid (Density: 0.984 g/cm3)

    Color

    Light yellow to yellow

    SMILES

    O=C1C(C)=C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(C2=C1C=CC=C2)=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Pure form -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    Ethanol : ≥ 50 mg/mL (110.94 mM)

    DMSO : 6.67 mg/mL (14.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2188 mL 11.0939 mL 22.1877 mL
    5 mM 0.4438 mL 2.2188 mL 4.4375 mL
    10 mM 0.2219 mL 1.1094 mL 2.2188 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (5.55 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (5.55 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 98.60%

    COA (241 KB) HNMR (260 KB) RP-HPLC (245 KB)

    取扱説明書 (2659 KB)
    参考文献
    細胞実験
    [2]

    Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    動物実験
    [4][5]

    Rats: For inducing full-thickness wound in rats, the excisional wound model is used. Five groups consisting of 8 rats each are used. Vitamin K cream (1% and 2%, w/w) is prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing is defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination is also done[5].

    Mice: Four-week-old C57BL/6J male mice are fed a 10% fat normal diet group or a 45% kcal high-fat diet group, with or without 200 mg/1000 g vitamin K1 (Normal diet + K1, high-fat diet + K1) and 200 mg/1000 g vitamin K2 (Normal diet + K2, high-fat diet + K2) for 12 weeks[4].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / Ethanol 1 mM 2.2188 mL 11.0939 mL 22.1877 mL 55.4693 mL
    5 mM 0.4438 mL 2.2188 mL 4.4375 mL 11.0939 mL
    10 mM 0.2219 mL 1.1094 mL 2.2188 mL 5.5469 mL
    Ethanol 15 mM 0.1479 mL 0.7396 mL 1.4792 mL 3.6980 mL
    20 mM 0.1109 mL 0.5547 mL 1.1094 mL 2.7735 mL
    25 mM 0.0888 mL 0.4438 mL 0.8875 mL 2.2188 mL
    30 mM 0.0740 mL 0.3698 mL 0.7396 mL 1.8490 mL
    40 mM 0.0555 mL 0.2773 mL 0.5547 mL 1.3867 mL
    50 mM 0.0444 mL 0.2219 mL 0.4438 mL 1.1094 mL
    60 mM 0.0370 mL 0.1849 mL 0.3698 mL 0.9245 mL
    80 mM 0.0277 mL 0.1387 mL 0.2773 mL 0.6934 mL
    100 mM 0.0222 mL 0.1109 mL 0.2219 mL 0.5547 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
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    Vitamin K1 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Vitamin K184-80-0Phylloquinone PhytomenadioneVitamin K 1Vitamin K-1OthersInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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