Vitamin K1-d7
Based on 1 Customer Validation
Vitamin K1-d7 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 1373049-34-3
- Formula: C31H39D7O2
- Molecular Weight:457.75
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1373049-34-3
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Unlabeled Cas 84-80-0
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Appearance Liquid (Density: 0.999 g/cm3)
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Molecular Weight 457.75
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Formula C31H39D7O2
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Color Colorless to light yellow
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SMILES
O=C1C(C([2H])([2H])[2H])=C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(C2=C1C([2H])=C([2H])C([2H])=C2[2H])=O
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Synonyms
Phylloquinone-d7; Phytomenadione-d7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMF : ≥ 25 mg/mL (54.61 mM)
Ethanol : ≥ 25 mg/mL (54.61 mM)
DMSO : ≥ 25 mg/mL (54.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22. [Content Brief]
[3]. Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721. [Content Brief]
[4]. Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8. [Content Brief]
[5]. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. [Content Brief]
[6]. Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMF / Ethanol / DMSO | 1 mM | 2.1846 mL | 10.9230 mL | 21.8460 mL | 54.6150 mL |
| 5 mM | 0.4369 mL | 2.1846 mL | 4.3692 mL | 10.9230 mL | |
| 10 mM | 0.2185 mL | 1.0923 mL | 2.1846 mL | 5.4615 mL | |
| 15 mM | 0.1456 mL | 0.7282 mL | 1.4564 mL | 3.6410 mL | |
| 20 mM | 0.1092 mL | 0.5461 mL | 1.0923 mL | 2.7307 mL | |
| 25 mM | 0.0874 mL | 0.4369 mL | 0.8738 mL | 2.1846 mL | |
| 30 mM | 0.0728 mL | 0.3641 mL | 0.7282 mL | 1.8205 mL | |
| 40 mM | 0.0546 mL | 0.2731 mL | 0.5461 mL | 1.3654 mL | |
| 50 mM | 0.0437 mL | 0.2185 mL | 0.4369 mL | 1.0923 mL |
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