2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Amperozide

Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors.

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Amperozide

Amperozide Chemische Struktur

CAS. Nr. : 75558-90-6

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Amperozide Related Antibodies

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Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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Beschreibung

Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors[1].

IC50 & Target

5-HT2A Receptor

26 nM (Ki)

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
95 μM
Compound: Amperozide
Cytotoxicity activity against human HepG2 cells after 24 hrs
Cytotoxicity activity against human HepG2 cells after 24 hrs
[PMID: 20547797]
Molekulargewicht

401.49

Formel

C23H29F2N3O
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (311.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4907 mL 12.4536 mL 24.9072 mL
5 mM 0.4981 mL 2.4907 mL 4.9814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4907 mL 12.4536 mL 24.9072 mL 62.2681 mL
5 mM 0.4981 mL 2.4907 mL 4.9814 mL 12.4536 mL
10 mM 0.2491 mL 1.2454 mL 2.4907 mL 6.2268 mL
15 mM 0.1660 mL 0.8302 mL 1.6605 mL 4.1512 mL
20 mM 0.1245 mL 0.6227 mL 1.2454 mL 3.1134 mL
25 mM 0.0996 mL 0.4981 mL 0.9963 mL 2.4907 mL
30 mM 0.0830 mL 0.4151 mL 0.8302 mL 2.0756 mL
40 mM 0.0623 mL 0.3113 mL 0.6227 mL 1.5567 mL
50 mM 0.0498 mL 0.2491 mL 0.4981 mL 1.2454 mL
60 mM 0.0415 mL 0.2076 mL 0.4151 mL 1.0378 mL
80 mM 0.0311 mL 0.1557 mL 0.3113 mL 0.7784 mL
100 mM 0.0249 mL 0.1245 mL 0.2491 mL 0.6227 mL
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Amperozide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amperozide75558-90-65-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2AntagonistD2AntipsychoticInhibitorinhibitorinhibit

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