Anti-Mouse CD18 Antibody (M18/2) 

Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

CD18

Anti-Mouse CD18 Antibody (M18/2) (2.5 µg/well, 1-2 days) does not inhibit lymphocyte function-associated antigen 1 (LFA-1)-mediated clusters in OT-I T cells^[1].
Anti-Mouse CD18 Antibody (M18/2) (10 µg/mL, 5 h) enhances murine procoagulant response.in Peritoneal exudate cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD18 Antibody (M18/2) (100 μg, daily) did not prolong allograft survival in BALB/c (H-2^d) hearts transplanted C3H/He (H-2^k) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

17079  [NCBI]

Q62192

in vivo Neutralization & Blocking

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD18 Antibody (M18/2)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zumwalde NA, et al. ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation. J Immunol. 2013 Oct 1;191(7):3681-93.  [Content Brief]

  [2]. Isobe M, et al. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science. 1992 Feb 28;255(5048):1125-7.  [Content Brief]

  [3]. Fan ST, et al. Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response. J Clin Invest. 1991 Jan;87(1):50-7.  [Content Brief]