2. Apoptosis Autophagy
  3. Apoptosis Autophagy Caspase
  4. Anticancer agent 325

Anticancer agent 325 is an apoptosis/autophagy inducer and anticancer agent. Anticancer agent 325 exhibits cytotoxic activity against gastric cancer cells, with no significant effect on healthy gastric epithelial cells. Anticancer agent 325 enhances the expression of activated/cleaved Caspase-3 to promote apoptosis. Anticancer agent 325 also enhances the cleavage of PARP, a downstream marker of apoptosis, promotes LC3B lipidation, and activates autophagy. Anticancer agent 325 can be used in the research of gastric cancer.

For research use only. We do not sell to patients.

Anticancer agent 325

Anticancer agent 325 Chemical Structure

CAS No. : 2922798-57-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anticancer agent 325 Related Antibodies

Top Publications Citing Use of Products

View All Caspase Isoform Specific Products:

View All Isoforms
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anticancer agent 325 is an apoptosis/autophagy inducer and anticancer agent. Anticancer agent 325 exhibits cytotoxic activity against gastric cancer cells, with no significant effect on healthy gastric epithelial cells. Anticancer agent 325 enhances the expression of activated/cleaved Caspase-3 to promote apoptosis. Anticancer agent 325 also enhances the cleavage of PARP, a downstream marker of apoptosis, promotes LC3B lipidation, and activates autophagy. Anticancer agent 325 can be used in the research of gastric cancer[1].

IC50 & Target[1]

Caspase 3

 

In Vitro

Anticancer agent 325 (compound 2d) (1.9-120.0 μM; 72 h) potently induces cytotoxicity in AGS and KATO III gastric cancer cells, with IC50 values of 30.9 μM and 19.0 μM, respectively; by contrast, it shows a higher IC50 value of 38.3 μM in non-malignant GES-1 gastric epithelial cells[1].
Anticancer agent 325 (30 μM; 24 h) modulates apoptosis and autophagy markers in AGS and KATO III gastric cancer cells, but exerts no such effect on non-cancerous GES-1 gastric epithelial cells[1].
Anticancer agent 325 (30 μM; 24 h) induces morphological changes of apoptosis and autophagosome formation in AGS gastric cancer cells, while it induces necrotic/apoptotic changes and autophagosome formation in KATO III gastric cancer cells, and also causes mitochondrial damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 325 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human gastric adenocarcinoma AGS cells, human signet ring cell carcinoma KATO III cells, noncancerous gastric epithelial immortalized GES-1 cells
Concentration: 1.9, 3.8, 7.5, 15.0, 30.0, 60.0, 120.0 μM
Incubation Time: 72 h
Result: Potently reduced viability of AGS cells with an IC50 of 30.9 μM.
Potently reduced viability of KATO III cells with an IC50 of 19.0 μM.
Reduced viability of GES-1 cells with an IC50 of 38.3 μM.
Induced dose-dependent cytotoxicity, with significant reductions in cell viability at multiple concentrations relative to untreated controls.
Molecular Weight

322.40

Formula

C18H26O5
CAS No.
SMILES

OC1=CC=C(OC(C(CCCCC)CC(OC(C)C)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anticancer agent 325 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 3252922798-57-8Anticancer agent325Anticancer agent-325ApoptosisAutophagyCaspasehealthy gastric epithelial cellsLC3B lipidationAGSCaspase-3gastric carcinomaPARP cleavageautophagy activationGES-1gastric cancer cellsKATO IIIInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anticancer agent 325
Cat. No.:
HY-183714
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.