Anticancer agent 325
Anticancer agent 325 is an apoptosis/autophagy inducer and anticancer agent. Anticancer agent 325 exhibits cytotoxic activity against gastric cancer cells, with no significant effect on healthy gastric epithelial cells. Anticancer agent 325 enhances the expression of activated/cleaved Caspase-3 to promote apoptosis. Anticancer agent 325 also enhances the cleavage of PARP, a downstream marker of apoptosis, promotes LC3B lipidation, and activates autophagy. Anticancer agent 325 can be used in the research of gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 2922798-57-8
- Formula: C18H26O5
- Molecular Weight:322.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase 3 |
Anticancer agent 325 (compound 2d) (1.9-120.0 μM; 72 h) potently induces cytotoxicity in AGS and KATO III gastric cancer cells, with IC50 values of 30.9 μM and 19.0 μM, respectively; by contrast, it shows a higher IC50 value of 38.3 μM in non-malignant GES-1 gastric epithelial cells[1].
Anticancer agent 325 (30 μM; 24 h) modulates apoptosis and autophagy markers in AGS and KATO III gastric cancer cells, but exerts no such effect on non-cancerous GES-1 gastric epithelial cells[1].
Anticancer agent 325 (30 μM; 24 h) induces morphological changes of apoptosis and autophagosome formation in AGS gastric cancer cells, while it induces necrotic/apoptotic changes and autophagosome formation in KATO III gastric cancer cells, and also causes mitochondrial damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human gastric adenocarcinoma AGS cells, human signet ring cell carcinoma KATO III cells, noncancerous gastric epithelial immortalized GES-1 cells
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Concentration:1.9, 3.8, 7.5, 15.0, 30.0, 60.0, 120.0 μM
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Incubation Time:72 h
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Result:Potently reduced viability of AGS cells with an IC50 of 30.9 μM.
Potently reduced viability of KATO III cells with an IC50 of 19.0 μM.
Reduced viability of GES-1 cells with an IC50 of 38.3 μM.
Induced dose-dependent cytotoxicity, with significant reductions in cell viability at multiple concentrations relative to untreated controls.
Chemical Information
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CAS No. 2922798-57-8
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Molecular Weight 322.40
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Formula C18H26O5
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SMILES
OC1=CC=C(OC(C(CCCCC)CC(OC(C)C)=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 325 Related Classifications
HY-183714 Related Classifications
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