Aurachin D

Cat. No.: HY-N7151 Pureté: 99.55%: Fiche technique
COA

SDS
Instruction de manipulation
FAQs
Technical Support

Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Aurachin D Chemical Structure

CAS No. : 108354-13-8

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

or Bulk Inquiry

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Other Forms of Aurachin D:

Aurachin D (Standard) Obtenir un devis

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Antibiotic:

Voir toutes les isoformes

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Activité biologique
Pureté et documentation
Références
Avis client

Description

Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L929	IC₅₀	1.3 μg/mL Compound: 3	Cytotoxicity against mouse L929 cells after 5 days by MTT assay Cytotoxicity against mouse L929 cells after 5 days by MTT assay	[PMID: 18922036]

Masse moléculaire

363.54

Formule

C₂₅H₃₃NO

CAS No.

108354-13-8

Appearance

Solid

Color

White to light brown

SMILES

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)NC2=C1C=CC=C2

Structure Classification

Initial Source

Microorganisms

myxobacteria

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (137.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7507 mL	13.7536 mL	27.5073 mL
5 mM	0.5501 mL	2.7507 mL	5.5015 mL
10 mM	0.2751 mL	1.3754 mL	2.7507 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.62%

Select Batch:

Fiche technique (267 KB) SDS (251 KB)

COA (242 KB) HNMR (273 KB) LCMS (87 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Kunze B, et al. The aurachins, new quinoline antibiotics from myxobacteria: production, physico-chemical and biological properties. J Antibiot (Tokyo). 1987 Mar;40(3):258-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7507 mL	13.7536 mL	27.5073 mL	68.7682 mL
	5 mM	0.5501 mL	2.7507 mL	5.5015 mL	13.7536 mL
	10 mM	0.2751 mL	1.3754 mL	2.7507 mL	6.8768 mL
	15 mM	0.1834 mL	0.9169 mL	1.8338 mL	4.5845 mL
	20 mM	0.1375 mL	0.6877 mL	1.3754 mL	3.4384 mL
	25 mM	0.1100 mL	0.5501 mL	1.1003 mL	2.7507 mL
	30 mM	0.0917 mL	0.4585 mL	0.9169 mL	2.2923 mL
	40 mM	0.0688 mL	0.3438 mL	0.6877 mL	1.7192 mL
	50 mM	0.0550 mL	0.2751 mL	0.5501 mL	1.3754 mL
	60 mM	0.0458 mL	0.2292 mL	0.4585 mL	1.1461 mL
	80 mM	0.0344 mL	0.1719 mL	0.3438 mL	0.8596 mL
	100 mM	0.0275 mL	0.1375 mL	0.2751 mL	0.6877 mL

Aurachin D Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurachin D108354-13-8FungalBacterialAntibioticAntibacterialAntifungalGram-positiveInhibitorinhibitorinhibit

Vos produits récemment consultés:

Nom du produit

Requested Quantity *

Nom du demandeur *

Civilité

Adresse e-mail *

Numéro de téléphone *

Department

Nom de l'organisation *

City

État

Country or Region *

Remarques

Nom du produit

Lot #

Nom du demandeur *

Adresse e-mail *

Numéro de téléphone

Department *