Autotaxin-IN-6 

Autotaxin-IN-6 (compound 23) is a potent autotaxin (ATX) inhibitor with an IC₅₀ value of 30 nM. Autotaxin-IN-6 can reduce cell migration. Autotaxin-IN-6 can be used for researching anticancer^[1].

Autotaxin-IN-6 (compound 23) inhibits ATX-stimulated HeLa cells and results in significantly decrease of LPA1 internalization of approximately 75%^[1].
Autotaxin-IN-6 prevents LPA1 activation and its Gαi- and PI3K-dependent signaling responses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

595.62

C₃₅H₅₄BNO₆

2800898-98-8

Solid

White to off-white

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Room temperature in continental US; may vary elsewhere.

• [1]. Clark JM, et al. Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. J Med Chem. 2022 Apr 28;65(8):6338-6351.  [Content Brief]