1. GPCR/G Protein
    Neuronal Signaling
  2. Histamine Receptor
  3. Buclizine dihydrochloride

Buclizine dihydrochloride 

Cat. No.: HY-A0128A Purity: >98.0%
Handling Instructions

Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat.

For research use only. We do not sell to patients.

Buclizine dihydrochloride Chemical Structure

Buclizine dihydrochloride Chemical Structure

CAS No. : 129-74-8

Size Price Stock Quantity
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].

In Vitro

Buclizine (0-100 μM, 72 h) inhibited cancer cell growth by binding to TCTP and induction of cell differentiation[3].

Cell Proliferation Assay[3].

Cell Line: MCF-7 cells[3].
Concentration: 0-100 μM.
Incubation Time: 72 h.
Result: The IC50 was 19.18 ± 5.32 μM.
In Vivo

Buclizine dihydrochloride (≥40 mg/kg) exhibits teratogenic effect[1].
Buclizine dihydrochloride exhibits the t1/2 of ~10 h via oral administration[2].

Animal Model: Eighty-seven mature female rats weighing 240±20 grams[1].
Dosage: 30-200 mg/kg.
Administration: From days 10 to 15.
Result: Exhibits teratogenic effect dose-dependently when ≥40 mg/kg.
Molecular Weight









Room temperature in continental US; may vary elsewhere.


Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)

Solvent & Solubility
In Vitro: 

DMSO : 2.5 mg/mL (4.94 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9765 mL 9.8824 mL 19.7648 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2


BuclizineHistamine ReceptorantiallergichistamineTCTPInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
Buclizine dihydrochloride
Cat. No.:
MCE Japan Authorized Agent: