1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Buclizine dihydrochloride

Buclizine dihydrochloride 

Cat. No.: HY-A0128A Purity: >98.0%
Handling Instructions

Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat.

For research use only. We do not sell to patients.

Buclizine dihydrochloride Chemical Structure

Buclizine dihydrochloride Chemical Structure

CAS No. : 129-74-8

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat[1][2][3].

In Vitro

Buclizine (0-100 μM, 72 h) inhibits cancer cell growth by binding to TCTP and induction of cell differentiation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3].

Cell Line: MCF-7 cells[3].
Concentration: 0-100 μM.
Incubation Time: 72 h.
Result: The IC50 was 19.18 ± 5.32 μM.
In Vivo

Buclizine dihydrochloride (≥40 mg/kg) exhibits teratogenic effect[1].
Buclizine dihydrochloride exhibits the t1/2 of ~10 h via oral administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eighty-seven mature female rats weighing 240±20 grams[1].
Dosage: 30-200 mg/kg.
Administration: From days 10 to 15.
Result: Exhibits teratogenic effect dose-dependently when ≥40 mg/kg.
Molecular Weight

505.95

Formula

C₂₈H₃₅Cl₃N₂

CAS No.

129-74-8

SMILES

CC(C1=CC=C(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C=C1)(C)C.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 2.5 mg/mL (4.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9765 mL 9.8824 mL 19.7648 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BuclizineHistamine ReceptorantiallergichistamineTCTPInhibitorinhibitorinhibit

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Buclizine dihydrochloride
Cat. No.:
HY-A0128A
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