Buclizine
Buclizine is an orally active antihistamine antiallergic compound. Buclizine is a potent teratogen in the rat and shows anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 82-95-1
- Formula: C28H33ClN2
- Molecular Weight:433.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells[2].
Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner[2].
Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Showed considerable growth inhibition (IC50=19.18 μM).
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Cell Line:MCF-7 cells
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Concentration:9.625, 19.25, 38.5, and 77 μM
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Incubation Time:72 hours
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Result:Increased the percentages of cells in the G1 phase to 73% at 77 μM.
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Cell Line:MCF-7 cells
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Concentration:0-75 μM
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Incubation Time:72 hours
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Result:Decreased TCTP expression by 40% at 75 μM.
Decreased cyclin D1, cyclin D3, CDK2 and CDK4 expression after 72 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eighty-seven mature female rats weighing 240±20 grams[3]
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Dosage:30, 40, 60, 100, and 200 mg/kg
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Administration:30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation
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Result:Resulted in malformations in 100% of the young at a dose level of 60-100 mg/kg.
Chemical Information
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CAS No. 82-95-1
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Molecular Weight 433.03
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Formula C28H33ClN2
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SMILES
CC(C1=CC=C(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C=C1)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gamal A E Mostafa, et al. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33. [Content Brief]
[2]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget. 2016 Mar 29;7(13):16818-39. [Content Brief]
[3]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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