129-74-8
129-74-8
Chemical Structure
Buclizine dihydrochloride
- CAS No.: 129-74-8
- Formula:C28H35Cl3N2
- Molecular Weight:505.95
IUPAC Name: 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride
InChIKey: SDBHDSZKNVDKNU-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)C=C1)(C)C.[H]Cl.[H]Cl
Biological Activity: Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity[1][2][3].
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Buclizine dihydrochloride | 99.62% | Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity. | ||||||||||||||||||||
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Buclizine dihydrochloride (Standard) | ≥98% | Buclizine (dihydrochloride) (Standard) is the analytical standard of Buclizine (dihydrochloride). This product is intended for research and analytical applications. Buclizine dihydrochloride is an orally active antihistamine antiallergic compound. Buclizine dihydrochloride is a potent teratogen in the rat and shows anti-tumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-A0128Buclizine -
Similarity Score 0.81
HY-B0349Meclizine dihydrochloride -
Similarity Score 0.80
HY-B0349BMeclizine dihydrochloride monohydrate -
Similarity Score 0.79
HY-135475(R)-Meclizine -
Similarity Score 0.79
HY-B0349AMeclizine -
Similarity Score 0.73
HY-W702286Cetirizine impurity 5 -
Similarity Score 0.73
HY-Z5984Cetirizine impurity 9 hydrochloride -
Similarity Score 0.71
HY-Z3816Cetirizine impurity 9 -
Similarity Score 0.71
HY-112067AChlorcyclizine hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Gamal A E Mostafa, et al. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33. [Content Brief]
- [2]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [Content Brief]
- [3]. Ean-Jeong Seo, et al. Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapy. Oncotarget. 2016 Mar 29;7(13):16818-39. [Content Brief]
