Meclizine dihydrochloride monohydrate
Based on 5 publication(s) in Google Scholar
Meclizine (Meclozine) dihydrochloride monohydrate, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride monohydrate is an effective anti-motion sickness agent. Meclizine dihydrochloride monohydrate crosses the blood-brain barrier. Meclizine dihydrochloride monohydrate is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride monohydrate can be used for the research of polyQ toxicity disorders, such as Huntington's disease.
For research use only. We do not sell to patients.
- CAS No.: 31884-77-2
- Formula: C25H31Cl3N2O
- Molecular Weight:481.89
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Meclizine dihydrochloride monohydrate
MoreAll Histamine Receptor Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
H1 Receptor |
In Vitro
Meclizine (Meclozine; 50 μM; 24 hours) dihydrochloride monohydrate significantly increases cell survival in STHdhQ111/111 cells at 24 h after the removal of serum, evidently by suppressing apoptosis, based on caspase 3 and 7 cleavage. The rescue is dose-dependent with an EC50 of 17.3 μm, and a maximum efficacy of 218% increased survival over vehicle. Meclizine dihydrochloride monohydrate protects striatal cells expressing polyglutamine (polyQ)-expanded huntingtin from serum withdrawal-induced apoptosis of mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:The murine striatal cells expressing wild-type (STHdhQ7/7) or mutant (STHdhQ111/111) huntingtin protein
-
Concentration:50 µM
-
Incubation Time:24 hours
-
Result:Significantly increased cell survival in STHdhQ111/111 cells at 24 h after the removal of serum.
-
Cell Line:Mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells
-
Concentration:50 µM
-
Incubation Time:0, 4, 10, 24 hours
-
Result:Suppressed apoptosis, based on caspase 3 and 7 cleavage.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:8-10 wk old male C57BL/6 mice[4]
-
Dosage:10, 30, 60 or 100 mg/kg
-
Administration:Administered intraperitoneally
-
Result:Protected mice from kidney ischemia-reperfusion injury.
Chemical Information
-
CAS No. 31884-77-2
-
Molecular Weight 481.89
-
Formula C25H31Cl3N2O
-
SMILES
CC1=CC(CN2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=CC=C4)CC2)=CC=C1.[H]Cl.[H]Cl.O
-
Synonyms
Meclozine dihydrochloride monohydrate
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
-
Journal Impact Factor
-
Most Recent
-
Phytomedicine
Ergothioneine alleviates hepatic steatosis by modulating PCYT2 to restore the phosphatidylethanolamine-ACOT8 homeostasis. [Abstract]2026 Aug:158:158238. PMID: 42275877 -
Am J Obstet Gynecol
Meclizine Improves Endometrial Repair and Reduces Simulated Menstrual Bleeding in Mice with Induced Adenomyosis. [Abstract]2024 Jul;231(1):113.e1-113.e13. PMID: 38367751 -
Ren Fail
2023 Dec;45(1):2230318. PMID: 37427767 -
J Biochem Mol Toxicol
Dihydroartemisinin Suppresses LOXL2-Mediated Glycerophospholipid Metabolic Reprogramming to Induce Cuproptosis in Colorectal Cancer Cells. [Abstract]2025 Aug;39(8):e70420. PMID: 40746272 -
Diabet Med
Wnt inhibitory factor 1 inhibits glycolysis through the HIF1α/PFKFB3 signalling pathway to regulate macrophage polarization and alleviate diabetic retinopathy. [Abstract]2026 May;43(5):e70285. PMID: 41814504
Purity & Documentation
References
[1]. Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.
[2]. Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300. [Content Brief]
[3]. Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR [Content Brief]
[4]. Seiji Kishi, et al. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Jul 29;2(9):1090-101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Meclizine dihydrochloride monohydrate Related Classifications
HY-B0349B Related Classifications
Powered by Bioz