1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Chlorcyclizine hydrochloride

Chlorcyclizine hydrochloride 

Cat. No.: HY-112067A Purity: 99.90%
Handling Instructions

Chlorcyclizine hydrochloride is a histamine H1 antagonist.

For research use only. We do not sell to patients.

Chlorcyclizine hydrochloride Chemical Structure

Chlorcyclizine hydrochloride Chemical Structure

CAS No. : 14362-31-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 90 In-stock
Estimated Time of Arrival: December 31
500 mg USD 190 In-stock
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Description

Chlorcyclizine hydrochloride is a histamine H1 antagonist.

IC50 & Target

Histamine H1[1]

In Vivo

Pregnant rats administered 30, 60, and 90mg/kg Chlorcyclizine during the sensitive period for palate development survived until scheduled sacrifice on Gestation Days (GDs) 17 or 21. The rats administered 60 or 90mg/kg Chlorcyclizine have transient adverse clinical signs (chromorhinorrhea, red peri-oral substance, urogenital staining, and scant stool) and a concomitant body weight loss of 7% and 11%, respectively, over the dosing interval. Rats administered 30mg/kg Chlorcyclizine do not exhibit any adverse clinical signs, but do not gain weight over the dose interval as would be expected during pregnancy. Based on the testing facility’s historical control database (16 studies, n=380). pregnant rats typically gain about 6% body weight from GDs 12 to 15[1].

Clinical Trial
Molecular Weight

337.29

Formula

C₁₈H₂₂Cl₂N₂

CAS No.

14362-31-3

SMILES

ClC(C=C1)=CC=C1C(C2=CC=CC=C2)N3CCN(C)CC3.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 77.5 mg/mL (229.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9648 mL 14.8240 mL 29.6481 mL
5 mM 0.5930 mL 2.9648 mL 5.9296 mL
10 mM 0.2965 mL 1.4824 mL 2.9648 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (7.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.58 mg/mL (7.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (7.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Rats[1]
Timed-mated CRL:CD [SD] female rats between 9 and 13 weeks of age at initiation of dosing and weighing between 245 and 363 g are used. Rats are administered a single daily oral gavage dose of 30, 60, or 90 mg/kg Chlorcyclizine (n=8/group) during the sensitive period for palate development, GDs 11 to 14. These doses are selected such that 30 mg/kg is a likely no-effect dose and higher doses of 60 and/or 90 mg/kg will induce a moderate or high incidence of fetal cleft palate. Given that CRL:CDs [SD] rats have an extremely low incidence of spontaneous cleft palate in the testing laboratory, as well as to avoid unnecessary use of animals, a methylcellulose control group is omitted[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
Chlorcyclizine hydrochloride
Cat. No.:
HY-112067A
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