Cercosporin (Synonyms: CGP049090)

Cat. No.: HY-N6743 Purity: 98.90%: Data Sheet
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Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM.

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Cercosporin 화학구조

CAS No. : 35082-49-6

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	견적 받기
50 mg	견적 받기

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Based on 1 Customer Validation

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View All PKC Isoform Specific Products:

View All Isoforms

PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations^[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM^[2].

IC₅₀ & Target

IC50: 0.6-1.3 μM (PKC)^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	10.8 3 Compound: 5	Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method Cytotoxicity against human BT549 cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
KB	IC₅₀	7.1 3 Compound: 5	Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method Cytotoxicity against human KB cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
SK-MEL	IC₅₀	3.6 3 Compound: 5	Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method Cytotoxicity against human SK-MEL cells assessed as viable cells by neutral red dye method	[PMID: 22530813]
SK-OV-3	IC₅₀	3.7 3 Compound: 5	Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method Cytotoxicity against human SKOV3 cells assessed as viable cells by neutral red dye method	[PMID: 22530813]

In Vitro

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD₅₀ value for the T98G cells (0.14 J cm²) is much less than the LD₅₀ value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm², respectively)^[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
Concentration:	0 μM, 1 μM, 2 μM, 3 μM
Incubation Time:	24 hours
Result:	Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

분자량

534.51

화학식

C₂₉H₂₆O₁₀

CAS No.

35082-49-6

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C=C(C(C2=C34)=C5C1=C(O)C(OC)=C(C[C@H](O)C)C5=C4C(C[C@H](O)C)=C6OC)OCOC2=CC(O)=C3C6=O

Structure Classification

Quinones

Initial Source

Microorganisms

Pseudocercosporella capsellae

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 10 mg/mL (18.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8709 mL	9.3544 mL	18.7087 mL
5 mM	0.3742 mL	1.8709 mL	3.7417 mL
10 mM	0.1871 mL	0.9354 mL	1.8709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.90%

Select Batch:

Data Sheet (284 KB) SDS (393 KB)

COA (264 KB) RP-HPLC (380 KB)

Handling Instructions (2659 KB)

References

[1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396. [Content Brief]

[2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8709 mL	9.3544 mL	18.7087 mL	46.7718 mL
	5 mM	0.3742 mL	1.8709 mL	3.7417 mL	9.3544 mL
	10 mM	0.1871 mL	0.9354 mL	1.8709 mL	4.6772 mL
	15 mM	0.1247 mL	0.6236 mL	1.2472 mL	3.1181 mL

Cercosporin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cercosporin35082-49-6CGP049090CGP 049090CGP-049090PKCProtein kinase CInhibitorinhibitorinhibit

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Cercosporin (Synonyms: CGP049090)

고객리뷰

Cercosporin Related Antibodies

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View All PKC Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Cercosporin Related Antibodies

몰농도 계산기

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Complete Stock Solution Preparation Table

Cercosporin Related Classifications

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