Cyclopropaneacetamide-Exatecan

Name: Cyclopropaneacetamide-Exatecan
Brand: MedChemExpress
SKU: HY-156617
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-156617 Reinheit: 99.60%: Data Sheet
COA

SDS
Handling Instructions
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Cyclopropaneacetamide-Exatecan is an Exatecan (HY-13631) analogue and an ADC Cytotoxin. Cyclopropaneacetamide-Exatecan can be used to synthesize ADC molecules for cancer research.

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Cyclopropaneacetamide-Exatecan Chemische Struktur

CAS. Nr. : 2414254-36-5

Größe	Verfügbarkeit	Menge

Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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500 mg	Angebot einholen

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Other Forms of Cyclopropaneacetamide-Exatecan:

(αR)-Cyclopropaneacetamide-Exatecan In-stock

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle ADC Payload Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Alle Topoisomerase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Topoisomerase Topo I Topo II DNA gyrase

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Cyclopropaneacetamide-Exatecan is an Exatecan (HY-13631) analogue and an ADC Cytotoxin. Cyclopropaneacetamide-Exatecan can be used to synthesize ADC molecules for cancer research^[1].

IC₅₀ & Target^[1]

Camptothecins

In Vitro

Cyclopropaneacetamide-Exatecan (Compound 2-A) can be used to synthesize ADC molecules, such as the anti-B7H3 antibody-Exatecan (HY-13631) analogue conjugate (Compound ADC-2)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

533.55

Formel

C₂₉H₂₈FN₃O₆

CAS. Nr.

2414254-36-5

Appearance

Solid

Color

Off-white to yellow

SMILES

O[C@@H](C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (187.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8742 mL	9.3712 mL	18.7424 mL
5 mM	0.3748 mL	1.8742 mL	3.7485 mL
10 mM	0.1874 mL	0.9371 mL	1.8742 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.60%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (264 KB) HNMR (299 KB) RP-HPLC (267 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Ying Hua, et al. Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof. Patent WO2020063673A1. 2020-04-02.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8742 mL	9.3712 mL	18.7424 mL	46.8560 mL
	5 mM	0.3748 mL	1.8742 mL	3.7485 mL	9.3712 mL
	10 mM	0.1874 mL	0.9371 mL	1.8742 mL	4.6856 mL
	15 mM	0.1249 mL	0.6247 mL	1.2495 mL	3.1237 mL
	20 mM	0.0937 mL	0.4686 mL	0.9371 mL	2.3428 mL
	25 mM	0.0750 mL	0.3748 mL	0.7497 mL	1.8742 mL
	30 mM	0.0625 mL	0.3124 mL	0.6247 mL	1.5619 mL
	40 mM	0.0469 mL	0.2343 mL	0.4686 mL	1.1714 mL
	50 mM	0.0375 mL	0.1874 mL	0.3748 mL	0.9371 mL
	60 mM	0.0312 mL	0.1562 mL	0.3124 mL	0.7809 mL
	80 mM	0.0234 mL	0.1171 mL	0.2343 mL	0.5857 mL
	100 mM	0.0187 mL	0.0937 mL	0.1874 mL	0.4686 mL