Cysteinylglycine (Synonyms: L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH)

Name: Cysteinylglycine
Brand: MedChemExpress
SKU: HY-113110
Rating: 4.5 (0 reviews)

Cat. No.: HY-113110 Purity: 99.79%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Cysteinylglycine (L-Cysteinylglycine; Cys-Gly) is a dipeptide formed by the peptide bond linkage between cysteine (Cysteine) and glycine (Glycine). Cysteinylglycine is an important metabolic intermediate in the human body, mainly derived from the degradation of glutathione (GSH). Cysteinylglycine reduces ferric iron to ferrous iron, drives the redox cycle of iron, generates reactive oxygen species (ROS), stimulates oxidative reactions, induces lipid peroxidation of human plasma LDL lipoproteins, and causes oxidative damage to DNA bases. Cysteinylglycine can be used as a biomarker to evaluate ischemic heart disease, breast cancer and other conditions.

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Custom Peptide Synthesis

Cysteinylglycine 화학구조

CAS No. : 19246-18-5

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 1 Customer Validation

Other Forms of Cysteinylglycine:

Cysteinylglycine TFA In-stock
Cysteinylglycine (Standard) In-stock

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
KB 3-1	IC₅₀	9.42 2 Compound: Cys-Gly	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB 3-1	IC₅₀	9.42 2 Compound: Cys-Gly	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	4.23 2 Compound: Cys-Gly	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	4.23 2 Compound: Cys-Gly	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB 3-1	IC₅₀	9.42 2 Compound: Cys-Gly	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	4.23 2 Compound: Cys-Gly	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]

In Vitro

Cysteinylglycine (48 h; 10 μM-50 μM) shows a significant 1.2- to 1.7-fold increase in human astrocytoma U373-MG cells after 48 h of treatment with various Nrf2 activators, compared with control cells^[1].
Cysteinylglycine (0.78-25 μM; incubated at 20℃ in the dark for 10 min) can be accurately quantified by this reversed-phase ion-pair liquid chromatography method, with a linear response range of 0.78 to 25 μM, a limit of detection < 2 pmol, and the adduct can be stably stored at -80℃ for 14 days^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

178.21

화학식

C₅H₁₀N₂O₃S

CAS No.

19246-18-5

Appearance

Solid

Color

White to off-white

Structure Classification

Others

Initial Source

Microorganisms

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

용액&용해도

In Vitro:

H₂O : 175 mg/mL (981.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6114 mL	28.0568 mL	56.1136 mL
5 mM	1.1223 mL	5.6114 mL	11.2227 mL
10 mM	0.5611 mL	2.8057 mL	5.6114 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.96%

Select Batch:

Data Sheet (271 KB) SDS (701 KB)

COA (244 KB) HNMR (248 KB) RP-HPLC (246 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Steele ML, et al. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox Biol. 2013;1(1):441-445. Published 2013 Sep 12. [Content Brief]

[2]. Mansoor MA, et al. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem. 1992;200(2):218-229. [Content Brief]

[3]. Lin J, et al. Plasma cysteinylglycine levels and breast cancer risk in women. Cancer Res. 2007;67(23):11123-11127. [Content Brief]

[4]. Houghton SC, et al. Plasma B-vitamin and one-carbon metabolites and risk of breast cancer before and after folic acid fortification in the United States. Int J Cancer. 2019;144(8):1929-1940. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.6114 mL	28.0568 mL	56.1136 mL	140.2839 mL
	5 mM	1.1223 mL	5.6114 mL	11.2227 mL	28.0568 mL
	10 mM	0.5611 mL	2.8057 mL	5.6114 mL	14.0284 mL
	15 mM	0.3741 mL	1.8705 mL	3.7409 mL	9.3523 mL
	20 mM	0.2806 mL	1.4028 mL	2.8057 mL	7.0142 mL
	25 mM	0.2245 mL	1.1223 mL	2.2445 mL	5.6114 mL
	30 mM	0.1870 mL	0.9352 mL	1.8705 mL	4.6761 mL
	40 mM	0.1403 mL	0.7014 mL	1.4028 mL	3.5071 mL
	50 mM	0.1122 mL	0.5611 mL	1.1223 mL	2.8057 mL
	60 mM	0.0935 mL	0.4676 mL	0.9352 mL	2.3381 mL
	80 mM	0.0701 mL	0.3507 mL	0.7014 mL	1.7535 mL
	100 mM	0.0561 mL	0.2806 mL	0.5611 mL	1.4028 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cysteinylglycine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cysteinylglycine (Synonyms: L-Cysteinylglycine; Cys-Gly; H-Cys-Gly-OH)

고객리뷰

Other Forms of Cysteinylglycine:

Cysteinylglycine Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

View All DNA/RNA Synthesis Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Cysteinylglycine Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Cysteinylglycine Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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