D-(+)-Trehalose (Synonyms: D-Trehalose; α,α-Trehalose)

Name: D-(+)-Trehalose
Brand: MedChemExpress
SKU: HY-N1132
Rating: 5.0 (9 reviews)

Cat. No.: HY-N1132 Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 99-20-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
100 mg	해외재고보유	Estimated Time of Arrival: December 31
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	견적 받기
5 g	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 9 publication(s) in Google Scholar

Other Forms of D-(+)-Trehalose:

9 Publications Citing Use of MCE D-(+)-Trehalose

Cell Proliferation/Viability Assay

Cell Autophagy Assay

RT-PCR

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.; D-(+)-Trehalose (trehalose) (50 mM; 24 h). Secondary screen cell-based assay for p62 expression. Dot plot representation of the effects of the 17 compounds on p62 expression after 24 hours of treatment and cell viability. Quantification of total p62 puncta area following treatment relative to the control DMSO 0.1%, using HCS Studio software. Each bar represents the mean ± SD (n=3).

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.; D-(+)-Trehalose (trehalose) (50 mM; 24 h). Cell-based screen for drug efficacy on membrane repair phenotype. Measurement of cell mortality after hypo-osmotic shock on DYSF^S1173X immortalized myoblasts pretreated for 24 hours with the 17 compounds. Each point represents the mean ± SD (n=4) of a representative experiment from three independent experiments.

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]; D-(+)-Trehalose (Tre) (50 mM; 2 h). The expression of cytoplasmic TFEB and nuclear TFEB was analyzed by western blotting.

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]; D-(+)-Trehalose (Tre) (50 mM; 2 h). Autophagic vacuoles in HK-2 cells were observed by the transmission electron microscope, and yellow arrows represented autophagic vacuoles (×4,000, or ×30,000).

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]; D-(+)-Trehalose (Tre) (50 mM; 2 h). The mRNA levels of fibronectin, collagen I, α-SMA and E-cadherin were assessed by RT-qPCR.

: D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]; D-(+)-Trehalose (Tre) (50 mM; 2 h). E-cadherin and α-SMA was detected by immunoinfluorence staining (Bar = 25 μm).

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

D-(+)-Trehalose (5000 μg/mL, 21 h) has no toxic effects on Chinese hamster ovary (CHO) cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-(+)-Trehalose (1-16 g/kg, p.o. or i.v., a single dose for 14 days) shows mild, self-limiting and restricted to piloerection and a softening of feces without systemic toxicity, and increases the blood glucose levels in mice and rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice and rats^[4]
Dosage:	1-16 g/kg
Administration:	p.o. or i.v., a single dose for 14 days
Result:	Resulted in mild, self-limiting and restricted to piloerection and a softening of feces and modest trehalose dose-dependent increases in blood glucose levels.

분자량

342.30

화학식

C₁₂H₂₂O₁₁

CAS No.

99-20-7

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O

Structure Classification

Initial Source

Endogenous metabolite

Widespread

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도

In Vitro:

H₂O : 200 mg/mL (584.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9214 mL	14.6071 mL	29.2141 mL
5 mM	0.5843 mL	2.9214 mL	5.8428 mL
10 mM	0.2921 mL	1.4607 mL	2.9214 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (292.14 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.94%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (252 KB) HNMR (131 KB) RP-HPLC (238 KB)

Handling Instructions (2659 KB)

References

[1]. Megarry AJ, et al. Amorphous trehalose dihydrate by cryogenic milling. Carbohydr Res. 2011 Jun 1;346(8):1061-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9214 mL	14.6071 mL	29.2141 mL	73.0354 mL
	5 mM	0.5843 mL	2.9214 mL	5.8428 mL	14.6071 mL
	10 mM	0.2921 mL	1.4607 mL	2.9214 mL	7.3035 mL
	15 mM	0.1948 mL	0.9738 mL	1.9476 mL	4.8690 mL
	20 mM	0.1461 mL	0.7304 mL	1.4607 mL	3.6518 mL
	25 mM	0.1169 mL	0.5843 mL	1.1686 mL	2.9214 mL
	30 mM	0.0974 mL	0.4869 mL	0.9738 mL	2.4345 mL
	40 mM	0.0730 mL	0.3652 mL	0.7304 mL	1.8259 mL
	50 mM	0.0584 mL	0.2921 mL	0.5843 mL	1.4607 mL
	60 mM	0.0487 mL	0.2435 mL	0.4869 mL	1.2173 mL
	80 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL
	100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.7304 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

D-(+)-Trehalose Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-(+)-Trehalose99-20-7D-Trehalose α,α-TrehaloseEndogenous MetaboliteInhibitorinhibitorinhibit

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D-(+)-Trehalose (Synonyms: D-Trehalose; α,α-Trehalose)

고객리뷰

Other Forms of D-(+)-Trehalose:

D-(+)-Trehalose Related Antibodies

9 Publications Citing Use of MCE D-(+)-Trehalose

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

D-(+)-Trehalose Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

D-(+)-Trehalose Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report