D-(+)-Trehalose dihydrate
Based on 9 publication(s) in Google Scholar
D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 6138-23-4
- Formula: C12H26O13
- Molecular Weight:378.33
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) D-(+)-Trehalose dihydrate
More- ACS Nano. 2025 May 27;19(20):19233-19254. [Abstract]
- Int J Pharm. 2024 Aug 18:124608. [Abstract]
- Microchem J. 2024 Jun, 201, 110666.
- Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
- Plant Pathol. 2025 Dec 30.
- J Ocul Pharmacol Ther. 2022 Jun;38(5):331-338. [Abstract]
- Res Sq. 2025 Oct 9.
- Res Sq. 2025 Jul 13.
- Res Sq. 2024 Sep 30.
Customer Validation & Images
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Cell Autophagy Assay
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Cell Proliferation/Viability Assay
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
Trehalose dihydrate is a safe, naturally occurring disaccharide used as a food ingredient and pharmaceutical excipient[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6138-23-4
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Appearance Solid
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Molecular Weight 378.33
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Formula C12H26O13
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O.[2 H2O]
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Synonyms
D-Trehalose dihydrate; α,α-Trehalose dihydrate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (9)
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Journal Impact Factor
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Most Recent
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ACS Nano
Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life. [Abstract]2025 May 27;19(20):19233-19254. PMID: 40359452 -
Int J Pharm
Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis. [Abstract]2024 Aug 18:124608. PMID: 39163929 -
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Ren Fail
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease. [Abstract]2024 Dec;46(1):2338933. PMID: 38616177
D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). The expression of cytoplasmic TFEB and nuclear TFEB was analyzed by western blotting.
D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). Autophagic vacuoles in HK-2 cells were observed by the transmission electron microscope, and yellow arrows represented autophagic vacuoles (×4,000, or ×30,000).
D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). The mRNA levels of fibronectin, collagen I, α-SMA and E-cadherin were assessed by RT-qPCR.
D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). E-cadherin and α-SMA was detected by immunoinfluorence staining (Bar = 25 μm).
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J Ocul Pharmacol Ther
Autophagy Protects Ocular Surface Against Overactivated Inflammation by Degrading Retinoic Acid-Induced Gene-I in Human Conjunctival Epithelial Cells. [Abstract]2022 Jun;38(5):331-338. PMID: 35613408 -
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D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.
D-(+)-Trehalose (trehalose) (50 mM; 24 h). Secondary screen cell-based assay for p62 expression. Dot plot representation of the effects of the 17 compounds on p62 expression after 24 hours of treatment and cell viability. Quantification of total p62 puncta area following treatment relative to the control DMSO 0.1%, using HCS Studio software. Each bar represents the mean ± SD (n=3).
D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.
D-(+)-Trehalose (trehalose) (50 mM; 24 h). Cell-based screen for drug efficacy on membrane repair phenotype. Measurement of cell mortality after hypo-osmotic shock on DYSFS1173X immortalized myoblasts pretreated for 24 hours with the 17 compounds. Each point represents the mean ± SD (n=4) of a representative experiment from three independent experiments.
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Solvent & Solubility
H2O : 150 mg/mL (396.48 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (132.16 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6432 mL | 13.2160 mL | 26.4320 mL | 66.0799 mL |
| 5 mM | 0.5286 mL | 2.6432 mL | 5.2864 mL | 13.2160 mL | |
| 10 mM | 0.2643 mL | 1.3216 mL | 2.6432 mL | 6.6080 mL | |
| 15 mM | 0.1762 mL | 0.8811 mL | 1.7621 mL | 4.4053 mL | |
| 20 mM | 0.1322 mL | 0.6608 mL | 1.3216 mL | 3.3040 mL | |
| 25 mM | 0.1057 mL | 0.5286 mL | 1.0573 mL | 2.6432 mL | |
| 30 mM | 0.0881 mL | 0.4405 mL | 0.8811 mL | 2.2027 mL | |
| 40 mM | 0.0661 mL | 0.3304 mL | 0.6608 mL | 1.6520 mL | |
| 50 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3216 mL | |
| 60 mM | 0.0441 mL | 0.2203 mL | 0.4405 mL | 1.1013 mL | |
| 80 mM | 0.0330 mL | 0.1652 mL | 0.3304 mL | 0.8260 mL | |
| 100 mM | 0.0264 mL | 0.1322 mL | 0.2643 mL | 0.6608 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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