Art. -Nr.: HY-N1132A

D-(+)-Trehalose dihydrate

Name: D-(+)-Trehalose dihydrate
Brand: MedChemExpress
SKU: HY-N1132A
Price: 25.00 USD
Availability: InStock
Rating: 5 (11 reviews)

(Synonyms: D-Trehalose dihydrate; α,α-Trehalose dihydrate)

11 Cited Publications

Kundenbewertung

Based on 11 publication(s) in Google Scholar

D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.

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Reinheit : 98.0%
CAS. Nr.: 6138-23-4
Formel: C₁₂H₂₆O₁₃
Molecular Weight:378.33

Speicherung:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

D-(+)-Trehalose dihydrate Chemical Structure

CAS. Nr.: 6138-23-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

D-(+)-Trehalose dihydrate, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

Trehalose dihydrate is a safe, naturally occurring disaccharide used as a food ingredient and pharmaceutical excipient^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 6138-23-4
Appearance Solid
Molecular Weight 378.33
Formel C₁₂H₂₆O₁₃
Color White to off-white
SMILES

O[C@H]1[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)O[C@H](CO)[C@@H](O)[C@@H]1O.[2 H2O]
Synonyms

D-Trehalose dihydrate; α,α-Trehalose dihydrate
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Plants
- Other Families Extract
- Animals
- Microorganisms
Widespread
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Publications (11)

All WBCell Proliferation/Viability AssayCell Autophagy AssayRT-PCRIF

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Journal Impact Factor

ACS Nano

Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life. [Abstract]

2025 May 27;19(20):19233-19254. PMID: 40359452
Extracell Vesicles Circ Nucl Acids

2026 Jul 31;7(3):1228-48.
Food Funct

Ameliorative effect of docosahexaenoic acid-acylated astaxanthin ester on diabetic nephropathy: association with the trehalose/HSP90AA1 and colon-kidney axis. [Abstract]

2026 May 18. PMID: 42149022
Int J Pharm

Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis. [Abstract]

2024 Oct 25:664:124608. PMID: 39163929
Microchem J

2024 Jun, 201, 110666.
Ren Fail

TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease. [Abstract]

2024 Dec;46(1):2338933. PMID: 38616177

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]

D-(+)-Trehalose (Tre) (50 mM; 2 h). The expression of cytoplasmic TFEB and nuclear TFEB was analyzed by western blotting.

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]

D-(+)-Trehalose (Tre) (50 mM; 2 h). Autophagic vacuoles in HK-2 cells were observed by the transmission electron microscope, and yellow arrows represented autophagic vacuoles (×4,000, or ×30,000).

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]

D-(+)-Trehalose (Tre) (50 mM; 2 h). The mRNA levels of fibronectin, collagen I, α-SMA and E-cadherin were assessed by RT-qPCR.

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]

D-(+)-Trehalose (Tre) (50 mM; 2 h). E-cadherin and α-SMA was detected by immunoinfluorence staining (Bar = 25 μm).
Plant Pathol

2025 Dec 30.
J Ocul Pharmacol Ther

Autophagy Protects Ocular Surface Against Overactivated Inflammation by Degrading Retinoic Acid-Induced Gene-I in Human Conjunctival Epithelial Cells. [Abstract]

2022 Jun;38(5):331-338. PMID: 35613408
Res Sq

2025 Oct 9.
Res Sq

2025 Jul 13.

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.

D-(+)-Trehalose (trehalose) (50 mM; 24 h). Secondary screen cell-based assay for p62 expression. Dot plot representation of the effects of the 17 compounds on p62 expression after 24 hours of treatment and cell viability. Quantification of total p62 puncta area following treatment relative to the control DMSO 0.1%, using HCS Studio software. Each bar represents the mean ± SD (n=3).

D-(+)-Trehalose dihydrate purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.

D-(+)-Trehalose (trehalose) (50 mM; 24 h). Cell-based screen for drug efficacy on membrane repair phenotype. Measurement of cell mortality after hypo-osmotic shock on DYSF^S1173X immortalized myoblasts pretreated for 24 hours with the 17 compounds. Each point represents the mean ± SD (n=4) of a representative experiment from three independent experiments.
Res Sq

2024 Sep 30.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 150 mg/mL (396.48 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6432 mL

13.2160 mL

26.4320 mL

5 mM

0.5286 mL

2.6432 mL

5.2864 mL

10 mM

0.2643 mL

1.3216 mL

2.6432 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (132.16 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (291 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Megarry AJ, et al. Amorphous trehalose dihydrate by cryogenic milling. Carbohydr Res. 2011 Jun 1;346(8):1061-4. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.6432 mL	13.2160 mL	26.4320 mL	66.0799 mL
	5 mM	0.5286 mL	2.6432 mL	5.2864 mL	13.2160 mL
	10 mM	0.2643 mL	1.3216 mL	2.6432 mL	6.6080 mL
	15 mM	0.1762 mL	0.8811 mL	1.7621 mL	4.4053 mL
	20 mM	0.1322 mL	0.6608 mL	1.3216 mL	3.3040 mL
	25 mM	0.1057 mL	0.5286 mL	1.0573 mL	2.6432 mL
	30 mM	0.0881 mL	0.4405 mL	0.8811 mL	2.2027 mL
	40 mM	0.0661 mL	0.3304 mL	0.6608 mL	1.6520 mL
	50 mM	0.0529 mL	0.2643 mL	0.5286 mL	1.3216 mL
	60 mM	0.0441 mL	0.2203 mL	0.4405 mL	1.1013 mL
	80 mM	0.0330 mL	0.1652 mL	0.3304 mL	0.8260 mL
	100 mM	0.0264 mL	0.1322 mL	0.2643 mL	0.6608 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

D-(+)-Trehalose dihydrate

11 Cited Publications

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D-(+)-Trehalose dihydrate

Publications Citing Use of MedChemExpress (MCE) D-(+)-Trehalose dihydrate

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