2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. D-(+)-Trehalose

トレハロース  (Synonyms: D-(+)-TrehaloseD-Trehalose; α,α-Trehalose)

製品番号: HY-N1132 純度: 99.94%
COA 取扱説明書 Technical Support

D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 99-20-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in Water USD 55 在庫あり
Solid
100 mg $50 在庫あり
500 mg $100 在庫あり
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5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of D-(+)-Trehalose:

トレハロース 関連抗体

Top Publications Citing Use of Products

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.

    D-(+)-Trehalose (trehalose) (50 mM; 24 h). Secondary screen cell-based assay for p62 expression. Dot plot representation of the effects of the 17 compounds on p62 expression after 24 hours of treatment and cell viability. Quantification of total p62 puncta area following treatment relative to the control DMSO 0.1%, using HCS Studio software. Each bar represents the mean ± SD (n=3).

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.

    D-(+)-Trehalose (trehalose) (50 mM; 24 h). Cell-based screen for drug efficacy on membrane repair phenotype. Measurement of cell mortality after hypo-osmotic shock on DYSFS1173X immortalized myoblasts pretreated for 24 hours with the 17 compounds. Each point represents the mean ± SD (n=4) of a representative experiment from three independent experiments.

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933.  [Abstract]

    D-(+)-Trehalose (Tre) (50 mM; 2 h). The expression of cytoplasmic TFEB and nuclear TFEB was analyzed by western blotting.

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933.  [Abstract]

    D-(+)-Trehalose (Tre) (50 mM; 2 h). Autophagic vacuoles in HK-2 cells were observed by the transmission electron microscope, and yellow arrows represented autophagic vacuoles (×4,000, or ×30,000).

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933.  [Abstract]

    D-(+)-Trehalose (Tre) (50 mM; 2 h). The mRNA levels of fibronectin, collagen I, α-SMA and E-cadherin were assessed by RT-qPCR.

    D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933.  [Abstract]

    D-(+)-Trehalose (Tre) (50 mM; 2 h). E-cadherin and α-SMA was detected by immunoinfluorence staining (Bar = 25 μm).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient[1][2][3][4].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外実験

    D-(+)-Trehalose (5000 μg/mL, 21 h) has no toxic effects on Chinese hamster ovary (CHO) cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    トレハロース 関連抗体
    体内実験

    D-(+)-Trehalose (1-16 g/kg, p.o. or i.v., a single dose for 14 days) shows mild, self-limiting and restricted to piloerection and a softening of feces without systemic toxicity, and increases the blood glucose levels in mice and rats[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice and rats[4]
    Dosage: 1-16 g/kg
    Administration: p.o. or i.v., a single dose for 14 days
    Result: Resulted in mild, self-limiting and restricted to piloerection and a softening of feces and modest trehalose dose-dependent increases in blood glucose levels.
    分子量

    342.30

    分子式

    C12H22O11
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O
    Structure Classification
    Initial Source

    Widespread
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    H2O : 200 mg/mL (584.28 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9214 mL 14.6071 mL 29.2141 mL
    5 mM 0.5843 mL 2.9214 mL 5.8428 mL
    10 mM 0.2921 mL 1.4607 mL 2.9214 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (292.14 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.94%

    COA (252 KB) HNMR (131 KB) RP-HPLC (238 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.9214 mL 14.6071 mL 29.2141 mL 73.0354 mL
    5 mM 0.5843 mL 2.9214 mL 5.8428 mL 14.6071 mL
    10 mM 0.2921 mL 1.4607 mL 2.9214 mL 7.3035 mL
    15 mM 0.1948 mL 0.9738 mL 1.9476 mL 4.8690 mL
    20 mM 0.1461 mL 0.7304 mL 1.4607 mL 3.6518 mL
    25 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9214 mL
    30 mM 0.0974 mL 0.4869 mL 0.9738 mL 2.4345 mL
    40 mM 0.0730 mL 0.3652 mL 0.7304 mL 1.8259 mL
    50 mM 0.0584 mL 0.2921 mL 0.5843 mL 1.4607 mL
    60 mM 0.0487 mL 0.2435 mL 0.4869 mL 1.2173 mL
    80 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9129 mL
    100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.7304 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    D-(+)-Trehalose Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    D-(+)-Trehalose99-20-7D-Trehalose α,α-TrehaloseEndogenous MetaboliteInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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