2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK STAT
  4. iJak-381

iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR).

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iJak-381

iJak-381 Estructura química

No. CAS : 1831144-46-7

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iJak-381 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

Ver todos los productos específicos de isoformas STAT:

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STAT3 STAT5 STAT6 STAT1

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Descripciòn

iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR)[1].

IC50 & Target

STAT6; JAK1; JAK2[1]
Peso molecular

612.03

Fòrmula

C28H28ClF2N9O3
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2N=CC=CN2N=C1)NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C5=CC(Cl)=CC=C5OC(F)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pureza y Documentación

Purity: 99.86%

SDS (393 KB)

COA (257 KB) HNMR (417 KB) RP-HPLC (266 KB) LCMS (94 KB)

Instrucciones de manejo (2659 KB)
Referencias
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iJak-381 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iJak-3811831144-46-7iJak381iJak 381JAKSTATJanus kinaseAsthmaCytokineImmunologyInhalationJanus KinaseKinase inhibitorLung-targetedRespiratoryInhibitorinhibitorinhibit

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Nombre del producto:
iJak-381
Cat. No.:
HY-125019
Cantidad:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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