2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. Calcium Channel Interleukin Related
  4. Manidipine

Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Manidipine

Manidipine 構造式

CAS 番号 : 89226-50-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $85 在庫あり
500 mg $215 在庫あり
1 g $340 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Manidipine:

Manidipine 関連抗体

Top Publications Citing Use of Products

Calcium Channel アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy[1][2][3][4][5][6][7][8].

Cellular Effect
Cell Line Type Value Description References
LLC-PK1 IC50
4.6 μM
Compound: Manidipine
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11145223]
LLC-PK1 IC50
4.65 μM
Compound: Manidipine
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 12128170]
体外実験

Manidipine (1 nM-1 μM; 1-4 h) inhibits the transcription of mRNA for IL-1β and GM-CSF, while enhancing the transcription of IL-6 gene in human mesangial cells stimulated by PDGF-BB[1].
Manidipine (0.1 nM-1 μM; 20-60 min) inhibits the ET-1-induced [Ca2+]i increase in A7r5 cells and glomerular mesangial cells[2].
Manidipine (1-5 μM; 18 h) completely inhibits IL-6 production induced by acLDL, oxLDL or TNF-α in human endothelial cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Manidipine 関連抗体
体内実験

Manidipine (1-10 mg/kg; p.o.; once a day; 7 days) reduces systolic blood pressure, increases plasma nitrite/nitrates, and shows a dose-dependent cardioprotective effect against ischemia-reperfusion injury in normocholesterolemic rats[6].
Manidipine (3 mg/kg; i.g.; once a day; 7 days) hydrochloride prevents Isoproterenol (HY-B0468)-induced left ventricular hypertrophy and the increase in ANP, collagen types I and III, and fibronectin mRNAs in rats[4].
Manidipine (0.05% in rat chow; p.o.; 2 months or 20 μg/kg; i.v.) hydrochloride shows antihypertensive effect in spontaneously hypertensive rats[5].
Manidipine (10-30 mg/kg; i.p.; before administration of agents that induced seizures) increases the latency to convulsions and the time of death in PTZ-induced seizure mice[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Spontaneously Hypertensive Rats (SHR) (age 8 weeks); Chronic hypertension renal microcirculation model and acute hypertension renal microcirculation model[5]
Dosage: 0.05% in rat chow (chronic), 20 μg/kg (acute)
Administration: Oral administration (chronic, 2 months); Intravenous injection (acute, once)
Result: Reduced systemic blood pressure, increased renal blood flow by dilating the afferent arterioles, and improved glomerular hypertension by dilating the efferent arterioles in the chronic model.
Decreased systemic blood pressure in the acute model.
Had different effects on renal microcirculation parameters, such as no significant change in SNGFR, SNGPF, or ΔP in some cases.
臨床実験
分子量

610.70

分子式

C35H38N4O6
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (163.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6375 mL 8.1873 mL 16.3747 mL
5 mM 0.3275 mL 1.6375 mL 3.2749 mL
10 mM 0.1637 mL 0.8187 mL 1.6375 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6375 mL 8.1873 mL 16.3747 mL 40.9366 mL
5 mM 0.3275 mL 1.6375 mL 3.2749 mL 8.1873 mL
10 mM 0.1637 mL 0.8187 mL 1.6375 mL 4.0937 mL
15 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7291 mL
20 mM 0.0819 mL 0.4094 mL 0.8187 mL 2.0468 mL
25 mM 0.0655 mL 0.3275 mL 0.6550 mL 1.6375 mL
30 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3646 mL
40 mM 0.0409 mL 0.2047 mL 0.4094 mL 1.0234 mL
50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.8187 mL
60 mM 0.0273 mL 0.1365 mL 0.2729 mL 0.6823 mL
80 mM 0.0205 mL 0.1023 mL 0.2047 mL 0.5117 mL
100 mM 0.0164 mL 0.0819 mL 0.1637 mL 0.4094 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Manidipine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Manidipine89226-50-6Calcium ChannelInterleukin RelatedCa2+ channelsCa channelsILhypotensiveischemia-reperfusion injuryventricular hypertrophyglomerular diseasesepilepsyInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Manidipine
製品番号:
HY-B0419
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.