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  4. Piperaquine tetraphosphate tetrahydrate

Piperaquine tetraphosphate tetrahydrate 

Art. -Nr.: HY-B1896B Reinheit: 98.0%
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Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin.

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Piperaquine tetraphosphate tetrahydrate

Piperaquine tetraphosphate tetrahydrate Chemische Struktur

CAS. Nr. : 915967-82-7

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Other Forms of Piperaquine tetraphosphate tetrahydrate:

Piperaquine tetraphosphate tetrahydrate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Piperaquine tetraphosphate tetrahydrate

Alle Parasite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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Beschreibung

Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin[1][2].

IC50 & Target

Plasmodium

 

In Vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage: 0, 10, 30, 90 mg/kg
Administration: A single i.p. administration
Result: The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model: Male Swiss mice (6 weeks old)[1]
Dosage: 90 mg/kg (Pharmacokinetic Analysis)
Administration: A single i.p. administration
Result: t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
Molekulargewicht

999.60

Formel

C29H32Cl2N6.4H3O4P.4H2O
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C2C(N3CCN(CCCN4CCN(C5=CC=NC6=CC(Cl)=CC=C56)CC4)CC3)=CC=NC2=C1.OP(O)(O)=O.[4].[4 H2O]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

H2O : 6 mg/mL (6.00 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0004 mL 5.0020 mL 10.0040 mL
5 mM 0.2001 mL 1.0004 mL 2.0008 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0004 mL 5.0020 mL 10.0040 mL 25.0100 mL
5 mM 0.2001 mL 1.0004 mL 2.0008 mL 5.0020 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Piperaquine tetraphosphate tetrahydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piperaquine tetraphosphate tetrahydrate915967-82-7Parasiteantimalarialartemisinindrug-basedcombinationACTInhibitorinhibitorinhibit

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