1. Anti-infection
  2. Parasite
  3. Piperaquine

Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Piperaquine tetraphosphate tetrahydrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Piperaquine Chemical Structure

Piperaquine Chemical Structure

CAS No. : 4085-31-8

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Other Forms of Piperaquine:

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  • Biological Activity

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Description

Piperaquine is a bisquinoline antimalarial agent. Piperaquine can be used in antimalarial research in combination with Artemisinin[1][2].

IC50 & Target

Plasmodium

 

In Vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

535.51

Formula

C29H32Cl2N6

CAS No.
SMILES

ClC1=CC=C2C(N3CCN(CCCN4CCN(C5=CC=NC6=CC(Cl)=CC=C56)CC4)CC3)=CC=NC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Piperaquine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Piperaquine
Cat. No.:
HY-B1896
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