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  3. Parasite
  4. Piperaquine phosphate

Piperaquine phosphate 

Cat. No.: HY-B1896A
Handling Instructions

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin.

For research use only. We do not sell to patients.

Piperaquine phosphate Chemical Structure

Piperaquine phosphate Chemical Structure

CAS No. : 85547-56-4

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma

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Description

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

In Vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage: 0, 10, 30, 90 mg/kg
Administration: A single i.p. administration
Result: The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model: Male Swiss mice (6 weeks old)[1]
Dosage: 90 mg/kg (Pharmacokinetic Analysis)
Administration: A single i.p. administration
Result: t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
Clinical Trial
Molecular Weight

633.51

Formula

C29H35Cl2N6O4P
CAS No.
SMILES

ClC1=CC=C2C(N3CCN(CCCN4CCN(C5=CC=NC6=CC(Cl)=CC=C56)CC4)CC3)=CC=NC2=C1.O=P(O)(O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Piperaquine85547-56-4Parasiteantimalarialartemisinindrug-basedcombinationtherapyACTInhibitorinhibitorinhibit

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