Piperaquine tetraphosphate tetrahydrate
Based on 1 publication(s) in Google Scholar
Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent. Piperaquine tetraphosphate tetrahydrate can be used in antimalarial research in combination with Artemisinin.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 915967-82-7
- Formula: C29H32Cl2N6.4H3O4P.4H2O
- Molecular Weight:999.60
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0176
Dihydroartemisinin
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HY-N0193
Artesunate
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HY-B0094
Artemisinin
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HY-17589A
Chloroquine
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HY-B0439
Sulfadoxine
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HY-N0402
Artemether
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HY-B0803
Lumefantrine
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HY-B1322A
Amodiaquine
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HY-14749A
Pyronaridine tetraphosphate
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HY-B1896BR
Piperaquine tetraphosphate tetrahydrate (Standard)
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HY-B1548
Benznidazole
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HY-N0176R
Dihydroartemisinin (Standard)
Publications Citing Use of MedChemExpress (MCE) Piperaquine tetraphosphate tetrahydrate
MoreAll Parasite Isoforms
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Biological Activity
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Plasmodium |
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
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Dosage:0, 10, 30, 90 mg/kg
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Administration:A single i.p. administration
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Result:The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
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Animal Model:Male Swiss mice (6 weeks old)[1]
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Dosage:90 mg/kg (Pharmacokinetic Analysis)
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Administration:A single i.p. administration
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Result:t1/2=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
Chemical Information
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CAS No. 915967-82-7
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Appearance Solid
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Molecular Weight 999.60
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Formula C29H32Cl2N6.4H3O4P.4H2O
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Color White to off-white
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SMILES
ClC1=CC=C2C(N3CCN(CCCN4CCN(C5=CC=NC6=CC(Cl)=CC=C56)CC4)CC3)=CC=NC2=C1.OP(O)(O)=O.[4].[4 H2O]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
H2O : 6 mg/mL (6.00 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0004 mL | 5.0020 mL | 10.0040 mL | 25.0100 mL |
| 5 mM | 0.2001 mL | 1.0004 mL | 2.0008 mL | 5.0020 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Piperaquine tetraphosphate tetrahydrate Related Classifications
HY-B1896B Related Classifications
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