1. Anti-infection
  2. Parasite
  3. Pyronaridine tetraphosphate

Pyronaridine tetraphosphate 

Cat. No.: HY-14749A Purity: 99.94%
COA Handling Instructions

Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection.

For research use only. We do not sell to patients.

Pyronaridine tetraphosphate Chemical Structure

Pyronaridine tetraphosphate Chemical Structure

CAS No. : 76748-86-2

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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50 mg USD 55 In-stock
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100 mg USD 77 In-stock
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250 mg USD 154 In-stock
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500 mg USD 264 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pyronaridine tetraphosphate:

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[1][2].

In Vitro

Pyronaridine tetraphosphate (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: P. falciparum: 3D7, K1, VS1, FCB, TM90C2a, FCR3
Concentration: 0-7 nM approximately
Incubation Time: 24 h
Result: Exhibited anti-P. falciparum activity with Mean IC50 values of 2.31 nM, 3.94 nM, 1.63 nM, 1.53 nM, 2.51 nM, 2.21 nM repectively.
In Vivo

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Echinococcus granulosus-infected mice model[2]
Dosage: 57 mg/kg
Administration: Oral administration, q.d. for 30 days
Result: Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.
Clinical Trial
Molecular Weight

910.03

Formula

C29H44ClN5O18P4

CAS No.
SMILES

OC1=C(CN2CCCC2)C=C(NC3=C4N=C(OC)C=CC4=NC5=CC(Cl)=CC=C53)C=C1CN6CCCC6.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (27.47 mM; ultrasonic and warming and heat to 60°C)

DMSO : 12.5 mg/mL (13.74 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0989 mL 5.4943 mL 10.9886 mL
5 mM 0.2198 mL 1.0989 mL 2.1977 mL
10 mM 0.1099 mL 0.5494 mL 1.0989 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (54.94 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.75 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.94%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pyronaridine tetraphosphate
Cat. No.:
HY-14749A
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