Pravastatin sodium (Synonyms: CS-514 sodium)

Name: Pravastatin sodium
Brand: MedChemExpress
SKU: HY-B0165A
Rating: 5.0 (7 reviews)

Cat. No.: HY-B0165A Purity: 99.02%: Data Sheet
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Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

For research use only. We do not sell to patients.

CAS No. : 81131-70-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
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Based on 7 publication(s) in Google Scholar

Other Forms of Pravastatin sodium:

7 Publications Citing Use of MCE Pravastatin sodium

•Research Square Preprint. 2022 Feb.

Cell Proliferation/Viability Assay

RT-PCR

Cell Imaging/Staining

: Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Growth inhibition following statin treatment of THP‐1 cells. To assess cell proliferation, 1 × 10⁴ cells were seeded in a six‐well plate and cultured with DMSO or Pravastatin (2 or 4 μM). Trypan blue dye exclusion assays were performed after 6 days of treatment (n = 4).

: Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Relative mRNA expression levels of KLF4 and DPYSL2A in THP‐1 cells treated by Pravastatin (2 or 4 μM). Total RNA was then extracted and analyzed by RT‐qPCR. Values were normalized to the GAPDH expression levels (n = 3).

: Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Cell surface expression levels of CD11b and CD14 in THP‐1 cells treated Pravastatin (2 or 4 μM) (n = 3).

: Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Morphological changes in THP‐1 cells treated with DMSO or Pravastatin (4 μM) for 6 days.

: Pravastatin sodium purchased from MedChemExpress. Usage Cited in: FEBS Open Bio. 2025 Aug 8. [Abstract]; Apoptosis of THP‐1 cells treated Pravastatin (2 or 4 μM). The annexin V‐positive cells were scored using flow cytometric analysis (n = 3).

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Description

Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC₅₀ of 5.6 μM.

IC₅₀ & Target

HMG-CoA reductase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	1.37 μM Compound: Pravastatin sodium	In vitro HMG-CoA reductase inhibitory activity to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line) In vitro HMG-CoA reductase inhibitory activity to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line)	[PMID: 11392538]
HepG2	IC₅₀	> 200 μM Compound: Pravastatin sodium	Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR	[PMID: 20457823]
Hepatocyte	IC₅₀	0.1 μM Compound: 1c	Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes. Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.	[PMID: 2231594]
Hepatocyte	IC₅₀	100 nM Compound: 2	The compound was tested for inhibition of Cholesterol synthesis from [14C]- Acetate in hepatocytes of rats. The compound was tested for inhibition of Cholesterol synthesis from [14C]- Acetate in hepatocytes of rats.	[PMID: 1895299]

In Vitro

Pravastatin (CS-514) is a member of the drug class of statins, used in combination with diet, exercise, and weight-loss for lowering cholesterol and preventing cardiovascular disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.51

Formula

C₂₃H₃₅NaO₇

CAS No.

81131-70-6

Appearance

Solid

Color

Off-white to Pale purple

SMILES

O[C@@H](C[C@@H](O)CC(O[Na])=O)CC[C@@H]([C@H](C=C1)C)[C@@](C1=C[C@@H](O)C2)([H])[C@H]2OC([C@@H](C)CC)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Penicillium Citrinum

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (223.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (111.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2396 mL	11.1980 mL	22.3959 mL
5 mM	0.4479 mL	2.2396 mL	4.4792 mL
10 mM	0.2240 mL	1.1198 mL	2.2396 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (223.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.38%

Select Batch:

Data Sheet (273 KB) SDS (419 KB)

COA (250 KB) HNMR (268 KB) RP-HPLC (245 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.2396 mL	11.1980 mL	22.3959 mL	55.9898 mL
	5 mM	0.4479 mL	2.2396 mL	4.4792 mL	11.1980 mL
	10 mM	0.2240 mL	1.1198 mL	2.2396 mL	5.5990 mL
	15 mM	0.1493 mL	0.7465 mL	1.4931 mL	3.7327 mL
	20 mM	0.1120 mL	0.5599 mL	1.1198 mL	2.7995 mL
	25 mM	0.0896 mL	0.4479 mL	0.8958 mL	2.2396 mL
	30 mM	0.0747 mL	0.3733 mL	0.7465 mL	1.8663 mL
	40 mM	0.0560 mL	0.2799 mL	0.5599 mL	1.3997 mL
	50 mM	0.0448 mL	0.2240 mL	0.4479 mL	1.1198 mL
	60 mM	0.0373 mL	0.1866 mL	0.3733 mL	0.9332 mL
	80 mM	0.0280 mL	0.1400 mL	0.2799 mL	0.6999 mL
	100 mM	0.0224 mL	0.1120 mL	0.2240 mL	0.5599 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Pravastatin sodium Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pravastatin81131-70-6CS-514CS514CS 514HMG-CoA Reductase (HMGCR)AutophagyFerroptosisInhibitorinhibitorinhibit

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Pravastatin sodium (Synonyms: CS-514 sodium)

Customer Review

Other Forms of Pravastatin sodium:

Pravastatin sodium Related Antibodies

7 Publications Citing Use of MCE Pravastatin sodium

Featured Recommendations

•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

Pravastatin sodium Related Antibodies

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Complete Stock Solution Preparation Table

Pravastatin sodium Related Classifications

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