2. Neuronal Signaling GPCR/G Protein
  3. Serotonin Transporter 5-HT Receptor
  4. (R)-Citalopram oxalate

(R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression.

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(R)-Citalopram oxalate

(R)-Citalopram oxalate Estructura química

No. CAS : 219861-53-7

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Other Forms of (R)-Citalopram oxalate:

(R)-Citalopram oxalate Related Antibodies

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Descripciòn

(R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression[1][2][3].

In Vitro

(R)-Citalopram (Ki = 330 nM) oxalate is approximately 60 times more weak than S-citalopram (Ki = 5 nM) in Iinhibition of the 5-HT-induced current in hSERT-expressing Xenopus oocytes[2].
R-citalopram oxalate attenuates the S-citalopram-induced inhibition of SERT[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(R)-Citalopram oxalate Related Antibodies
In Vivo

(R)-Citalopram (1-7.8 mg/kg; s.c.; single dose) oxalateant's agonistic behaviour appears to be specific for S-citalopram[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMRI/BOM (male, 18-25 g)[2]
Dosage: 1 mg/kg; 2 mg/kg; 3.9 mg/kg; 7.8 mg/kg
Administration: s.c.; single dose
Result: When coapplied with S-citalopram in ratios of 2 : 1 and 4 : 1, there was – except for 2 mg S-citalopram + 3.9 mg R-citalopram – a statistically significant reduction in the effect of S-citalopram.
Appeared to be antagonist specific for S-citalopram.
Peso molecular

414.43

Fòrmula

C22H23FN2O5
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

OC(C(O)=O)=O.CN(C)CCC[C@@]1(C2=CC=C(C=C2)F)C3=CC=C(C#N)C=C3CO1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Pureza y Documentación

Purity: 99.52%

SDS (393 KB)

COA (254 KB) Elemental Analysis Report (112 KB)

Instrucciones de manejo (2659 KB)
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(R)-Citalopram oxalate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Citalopram219861-53-7Serotonin Transporter5-HT Receptor5-HTTSERTSLC6A4Serotonin Receptor5-hydroxytryptamine ReceptorR-(-) enantiomers5-HT transporterdepressionInhibitorinhibitorinhibit

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Nombre del producto:
(R)-Citalopram oxalate
Cat. No.:
HY-110289
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