2. PI3K/Akt/mTOR
  3. Akt PI3K
  4. Recilisib sodium

Recilisib sodium  (Synonyms: ON 01210 sodium)

製品番号: HY-101625A
取扱説明書 Technical Support

Recilisib sodium (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells.

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CAS 番号 : 922139-31-9

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

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Recilisib sodium 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Proliferation/Viability Assay
WB

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb 12:139:156464.  [Abstract]

    Recilisib significantly reversed BRU-induced suppression of lipid metabolism in 143B, U2OS cells.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep 7:135:156022.  [Abstract]

    Recilisib partially reversed the proliferation inhibitory effect of HA in RBE and HuccT1 cells.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Sep 7:135:156022.  [Abstract]

    Recilisib indeed elevated the protein expression of P-mTOR (Ser2448), P-PI3K (Tyr607), and P-AKT (S473) following HA-induced inhibition PI3K-AKT-mTOR activator recilisib reversed the effect of HA on ICC.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):463-482.

    Recilisib (10 μM) activated the PI3K/AKT pathway (via recilisib), leading to an increased HCC cell viability in the cotreatment group compared to the Rk3 only group.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2023 May;13(5):463-482.

    Recilisib (10 μM) increased the protein expression of CDK4, cyclin D1 and P62, as well as decreased the protein expression of Bax, c-PARP and LC3II/LC3I in HepG2 and HCC-LM3 cells with 100 μM Rk3.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2020 Mar 15;147:79-88.  [Abstract]

    Measurement of ERK1/2 and NF-κB p65. Effect of GFP-A and Recilisib (activator of Akt) (10 μmol/L) on the expression of phosphorylated ERK1/2 in HT-29 cells. Cells are treated with 180 μg/mL GFP-A in the presence or absence of Recilisib for different durations of time.

    Recilisib sodium purchased from MedChemExpress. Usage Cited in: Environ Toxicol. 2020 Dec;35(12):1299-1307.  [Abstract]

    FaDu cells with AGK overexpression is treated with the PI3K inhibitor LY294002, and Cal27 cells with AGK knockdown is treated with PI3K activator Recilisib (50 μM). The inhibitory effect of LY294002 and promoting effects of Recilisib on PI3K/Akt signaling is confirmed by Western blot analysis.

    Akt アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Akt Akt1 Akt2 Akt3

    PI3K アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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    製品説明

    Recilisib sodium (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells[1].

    体外実験

    Recilisib sodium (up to 50 μM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in the number of cells in S-phase at 50 μM. Continuous exposure of Recilisib sodium (100 μM) does not result in cell death. Recilisib sodium treatment does not inhibit the colony forming potential of human bone marrow cells. Recilisib sodium provides dose dependent protection of human bone marrow cells at all three doses of IR. Recilisib sodium activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib sodium treatment in combination with radiation alters the MAPK signaling pathway[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Recilisib sodium 関連抗体
    体内実験

    Recilisib sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    358.77

    分子式

    C16H12ClNaO4S
    CAS 番号
    SMILES

    O=C(C1=CC=C(C=C1)/C=C/S(=O)(CC2=CC=C(C=C2)Cl)=O)O[Na]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    純度とドキュメンテーション
    参考文献
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    Recilisib sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Recilisib922139-31-9ON 01210ON01210ON-01210AktPI3KPKBProtein kinase BPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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    製品名:
    Recilisib sodium
    製品番号:
    HY-101625A
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