2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. HDAC Apoptosis
  4. Romidepsin

Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis.

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Romidepsin

Romidepsin Estructura química

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Romidepsin Related Antibodies

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Descripciòn

Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2].

In Vitro

Romidepsin (GMP) (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner[2].
Romidepsin (GMP) (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells[2].
Romidepsin (GMP) (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Romidepsin Related Antibodies

Cell Proliferation Assay[2]

Cell Line: HCC cells
Concentration: 0 nM; 10 nM; 20 nM; 30 nM; 40 nM; 50 nM; 60 nM; 70 nM; 80 nM
Incubation Time: 0 hours; 12 hours; 24 hours; 48 hours; 72 hours
Result: Inhibited HCC cells proliferation.

Cell Cycle Analysis[2]

Cell Line: HCC cells
Concentration: 0 nM; 15 nM; 30 nM; 60 nM
Incubation Time: 12 hours; 24 hours; 48 hours
Result: Caused a G2/M arrest.

Western Blot Analysis[2]

Cell Line: HCC cells
Concentration: 0 nM; 15 nM; 30 nM; 60 nM
Incubation Time: 12 hours; 24 hours; 48 hours
Result: Increaesd c-caspase-3, c-caspase-9, and c-PARP expression in HCC cells.
In Vivo

Romidepsin (GMP) (intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days) inhibited the tumor growth, reveals a higher expression of p-cdc25C, ki67, c-caspase-3 and c-PARP, and a lower expression of Ki-67 in Romidepsin treated tumors [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with Huh7 cells[2]
Dosage: 0.5 and 1 mg/kg
Administration: Intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days
Result: Suppressed tumor growth in mouse xenograft models.
Peso molecular

540.70

Fòrmula

C24H36N4O6S2
SMILES

C/C=C(NC([C@@H](CSSCC/C=C/[C@@H](O1)CC2=O)NC([C@@H](C(C)C)N2)=O)=O)/C(N[C@@H](C(C)C)C1=O)=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Romidepsin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Romidepsin (GMP)FK 228 (GMP)FR 901228 (GMP)NSC 630176 (GMP)HDACApoptosisHistone deacetylasesInhibitorinhibitorinhibit

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HY-15149G
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