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( )-Pinoresinol diacetate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (3) Carboxylesterase (CES) (1) Drug Derivative (1) Estrogen Receptor/ERR (2) Fungal (2) GCGR (1) Glucocorticoid Receptor (1) Glycosidase (4) Heme Oxygenase (HO) (2) Keap1-Nrf2 (2) mTOR (2) NF-κB (2) NO Synthase (2) Orthopoxvirus (1) p38 MAPK (2) Phosphodiesterase (PDE) (2) PI3K (2) PKA (2) PKC (2) Reference Standards (4) TGF-beta/Smad (2) Tyrosinase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0657

Pinoresinol Diglucoside 1 Publications Verification	NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis .

HY-N6253

*Pinoresinol* 1 Publications Verification (+)-Pinoresinol	Apoptosis	Cancer
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

HY-P3469A

Dasiglucagon acetate	GCGR	Metabolic Disease
Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Cancer
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-126067

(-)-Pinoresinol	Glycosidase Apoptosis	Inflammation/Immunology
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

HY-N2180

(+)-Eudesmin (+)-Eudesmine	PKC PKA p38 MAPK NO Synthase	Neurological Disease
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-N0946

*(-)-Pinoresinol* 4-O-glucoside** (-)-Pinoresinol 4-O-β-D-glucopyranoside	Glycosidase	Metabolic Disease
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-107932

Triamcinolone diacetate	Glucocorticoid Receptor	Inflammation/Immunology
Triamcinolone diacetate is a synthetic derivative of glucocorticoid. Triamcinolone diacetate has anti-inflammatory activity. Triamcinolone diacetate can be used in research on dermatomyositis, Bell's palsy and rheumatoid arthritis .

HY-N6253R

Pinoresinol (Standard) (+)-Pinoresinol (Standard)	Reference Standards Apoptosis	Cancer
Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

HY-N0957

(±)-Pinoresinol	Fungal	Infection
(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity .

HY-N3921

Gancaonin I	Carboxylesterase (CES)	Cancer
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-N0954

*(+)-Pinoresinol* diacetate**	Fungal	Infection Inflammation/Immunology
(+)-Pinoresinol diacetate is an antifungal agent that can be isolated from Sambucus williamsii .

HY-147015

HOE961	Orthopoxvirus	Infection
HOE961, the diacetate ester proagent of S2242, is active against respiratory cowpox virus infections, is orally active in infection models. Anti-orthopoxvirus activity .

HY-N2168R

Pinoresinol 4-O-β-D-glucopyranoside (Standard) (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)	Glycosidase Reference Standards Estrogen Receptor/ERR Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Cancer
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N0657R

Pinoresinol Diglucoside (Standard)	Reference Standards NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Pinoresinol Diglucoside (Standard) is the analytical standard of Pinoresinol Diglucoside (HY-N0657). This product is intended for research and analytical applications. Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis.

HY-N7982

*(+)-Pinoresinol* monomethyl ether O-β-D-glucoside**	Others	Others
(+)-Pinoresinol monomethyl ether O-β-D-glucoside (Compound 6) is a natural product that can be isolated from the stems of Tinospora sinensis .

HY-N2180R

(+)-Eudesmin (Standard) (+)-Eudesmine (Standard)	Reference Standards PKC PKA p38 MAPK NO Synthase	Neurological Disease
Pinoresinol dimethyl ether (Standard) is the analytical standard of Pinoresinol dimethyl ether (HY-N2180). This product is intended for research and analytical applications. Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-N17513

4'-Methoxy-pinoresinol	Drug Derivative	Others
4'-Methoxy-pinoresinol is a natural product that can be found in Forsythia suspensa?(Thunb.) Vahl.

HY-N17896

Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside	Tyrosinase	Cancer
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products .

HY-N17493

Spinosic acid A	Others	Others
Spinosic acid A is a triterpene sapogenin. Spinosic acid A is found in Randia spinosa(Thunb.) Poir. .

Cat. No.	Product Name	Target	Research Area

HY-P3469A

Dasiglucagon acetate	GCGR	Metabolic Disease
Dasiglucagon acetate is a human glucagon analog, and can increase plasma glucose. Dasiglucagon can be used in hypoglycemia research .

Pinoresinol Diglucoside 1 Publications Verification	Structural Classification Eucommia ulmoides Oliver Classification of Application Fields Lignans Other Diseases Eucommiaceae Phenylpropanoids Plants Disease Research Fields Source Classification	NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K
Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis .

*Pinoresinol* 1 Publications Verification (+)-Pinoresinol	Structural Classification other families Classification of Application Fields Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Apoptosis
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Monophenols other families Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

(-)-Pinoresinol	Structural Classification other families Hernandia nymphaeifolia (C. Presl) Kubitzki Lignans Phenylpropanoids Plants Source Classification	Glycosidase Apoptosis
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest .

(+)-Eudesmin (+)-Eudesmine	Neurological Disease Classification of Application Fields Magnoliaceae Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Disease Research Fields Source Classification	PKC PKA p38 MAPK NO Synthase
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

*(-)-Pinoresinol* 4-O-glucoside** (-)-Pinoresinol 4-O-β-D-glucopyranoside	Cicer arietinum L. Plants Compositae Saccharides Monosaccharides Source Classification	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

Pinoresinol (Standard) (+)-Pinoresinol (Standard)	Structural Classification other families Lignans Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards Apoptosis
Pinoresinol (Standard) is the analytical standard of Pinoresinol. This product is intended for research and analytical applications. Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis .

(±)-Pinoresinol	Structural Classification Melia azedarach L. Phenols Polyphenols Plants Meliaceae Source Classification	Fungal
(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity .

Gancaonin I	Flavonoids Classification of Application Fields Leguminosae Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification Cancer	Carboxylesterase (CES)
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

*(+)-Pinoresinol* diacetate**	other families Ketones, Aldehydes, Acids Adiantum capillus-veneris L. Plants Source Classification	Fungal
(+)-Pinoresinol diacetate is an antifungal agent that can be isolated from Sambucus williamsii .

Pinoresinol 4-O-β-D-glucopyranoside (Standard) (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)	Structural Classification Monophenols other families Lignans Phenols Phenylpropanoids Plants Source Classification	Glycosidase Reference Standards Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active α-glucosidase inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

Pinoresinol Diglucoside (Standard)	Structural Classification Eucommia ulmoides Oliver Lignans Eucommiaceae Phenylpropanoids Plants Source Classification	Reference Standards NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K
Pinoresinol Diglucoside (Standard) is the analytical standard of Pinoresinol Diglucoside (HY-N0657). This product is intended for research and analytical applications. Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis.

*(+)-Pinoresinol* monomethyl ether O-β-D-glucoside**	Plants Menispermaceae Saccharides Tinospora sinensis (Lour.) Merr. Monosaccharides Source Classification	Others
(+)-Pinoresinol monomethyl ether O-β-D-glucoside (Compound 6) is a natural product that can be isolated from the stems of Tinospora sinensis .

(+)-Eudesmin (Standard) (+)-Eudesmine (Standard)	Structural Classification Magnoliaceae Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Source Classification	Reference Standards PKC PKA p38 MAPK NO Synthase
Pinoresinol dimethyl ether (Standard) is the analytical standard of Pinoresinol dimethyl ether (HY-N2180). This product is intended for research and analytical applications. Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

4'-Methoxy-pinoresinol	Structural Classification Lignans Araucariaceae Phenylpropanoids Plants Araucaria araucana (Molina) C. Koch Source Classification	Drug Derivative
4'-Methoxy-pinoresinol is a natural product that can be found in Forsythia suspensa?(Thunb.) Vahl.

Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside	Structural Classification Lignans Sapindaceae Phenylpropanoids Acer buergerianum Miq. Plants Source Classification	Tyrosinase
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products .

Spinosic acid A	Triterpenes Structural Classification Terpenoids Rubiaceae Catunaregam spinosa (Thunb.) Tirveng. Plants Source Classification	Others
Spinosic acid A is a triterpene sapogenin. Spinosic acid A is found in Randia spinosa(Thunb.) Poir. .

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( )-Pinoresinol diacetate

Inhibitors & Agonists

Peptides

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Natural
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