Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products.
For research use only. We do not sell to patients.
- CAS No.: 123564-49-8
- Formula: C31H40O15
- Molecular Weight:652.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside (compound 9) (10-100 μM) inhibits melanogenesis in α-MSH-stimulated B16 mouse melanoma cells, reducing melanin content to 40.9% of control at 100 μM, with weak cytotoxicity (80.6% cell viability at 100 μM)[1].
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside (10-50 μM; 48 h) modulates melanogenic protein expression in α-MSH-stimulated B16 mouse melanoma cells, reducing tyrosinase and TRP-2 levels and increasing MITF and TRP-1 levels in a concentration-dependent manner after 48 h of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:α-MSH-stimulated B16 mouse melanoma cells
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Concentration:10-50 μM
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Incubation Time:48 h
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Result:Reduced protein levels of tyrosinase and TRP-2 in a concentration-dependent manner.
Increased protein levels of MITF and TRP-1 in a concentration-dependent manner.
Chemical Information
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CAS No. 123564-49-8
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Molecular Weight 652.64
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Formula C31H40O15
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SMILES
COC1=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O[C@H]3[C@@H]([C@](O)(CO3)CO)O)C=CC([C@@H]4[C@]5([H])[C@@](CO4)([H])[C@@H](C6=CC(OC)=C(C=C6)O)OC5)=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside Related Classifications
HY-N17896 Related Classifications
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