Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside 

Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products^[1].

Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside (compound 9) (10-100 μM) inhibits melanogenesis in α-MSH-stimulated B16 mouse melanoma cells, reducing melanin content to 40.9% of control at 100 μM, with weak cytotoxicity (80.6% cell viability at 100 μM)^[1].
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside (10-50 μM; 48 h) modulates melanogenic protein expression in α-MSH-stimulated B16 mouse melanoma cells, reducing tyrosinase and TRP-2 levels and increasing MITF and TRP-1 levels in a concentration-dependent manner after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

652.64

C₃₁H₄₀O₁₅

123564-49-8

COC1=C(O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O[C@H]3[C@@H]([C@](O)(CO3)CO)O)C=CC([C@@H]4[C@]5([H])[C@@](CO4)([H])[C@@H](C6=CC(OC)=C(C=C6)O)OC5)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Akihisa T, et al. Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum. Chem Biodivers. 2013;10(2):167-176.