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Cat. No.: HY-N0946

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(-)-Pinoresinol 4-O-glucoside

Name: (-)-Pinoresinol 4-O-glucoside
Brand: MedChemExpress
SKU: HY-N0946
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: (-)-Pinoresinol 4-O-β-D-glucopyranoside)

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(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 41607-20-9
Formula: C₂₆H₃₂O₁₁
Molecular Weight:520.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(-)-Pinoresinol 4-O-glucoside Chemical Structure

CAS No.: 41607-20-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 48.13 µM (α-Glucosidase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>30 μM Compound: 9	Anticancer activity against human A549 cells by SRB assay Anticancer activity against human A549 cells by SRB assay	[PMID: 21420296]
BV-2	IC₅₀	144.33 μM Compound: 9	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of lipopolysaccharide induced NO production Antiinflammatory activity in mouse BV2 cells assessed as inhibition of lipopolysaccharide induced NO production	[PMID: 21420296]
N9	IC₅₀	>100 μM Compound: 20	Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 28073678]
RAW264.7	IC₅₀	>0.3 mM Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
RAW264.7	IC₅₀	>0.3 μM/mL Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs	[PMID: 18986199]
SK-MEL-2	IC₅₀	>30 μM Compound: 9	Anticancer activity against human SK-MEL-2 cells by SRB assay Anticancer activity against human SK-MEL-2 cells by SRB assay	[PMID: 21420296]
SK-OV-3	IC₅₀	>30 μM Compound: 9	Anticancer activity against human SKOV3 cells by SRB assay Anticancer activity against human SKOV3 cells by SRB assay	[PMID: 21420296]
XF498	IC₅₀	25.37 μM Compound: 9	Anticancer activity against human XF498 cells by SRB assay Anticancer activity against human XF498 cells by SRB assay	[PMID: 21420296]

In Vitro

(-)-Pinoresinol 4-O-glucoside (0, 10, 30 µM; 24 h) increases cell migration during the differentiation of pre-osteoblasts in osteogenic supplement medium (OS) containing 50 μg/mL^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 7 days) increases the early differentiation and increases mineralized nodule formation during differentiation of pre-Osteoblasts^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases the expressio of BMP2, ALP, OCN mRNA levels in pre-osteoblasts^[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases protein level of BMP2, p-Smad1/5/8, RUNX2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

pre-osteoblasts
Concentration:

10, 30 µM
Incubation Time:

3 days
Result:

Upregulated the mRNA level of BMP2 and its target osteoblast genes, ALP and osteocalcin (OCN).

Western Blot Analysis^[1]

Cell Line:

pre-osteoblasts
Concentration:

10, 30 µM
Incubation Time:

3 days
Result:

Enhanced protein level of BMP2, followed by the phosphorylation of Smad1/5/8 and the expression of RUNX2.

In Vivo

(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

27-30 g, Male Swiss albino mice^[2]
Dosage:

50 mg/kg
Administration:

P.o.; twenty days
Result:

Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.

Chemical Information

CAS No. 41607-20-9
Appearance Solid
Molecular Weight 520.53
Formula C₂₆H₃₂O₁₁
Color White to light yellow
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C([C@@H]3OC[C@]4([H])[C@@]3([H])CO[C@H]4C5=CC=C(O)C(OC)=C5)C=C2OC
Synonyms

(-)-Pinoresinol 4-O-β-D-glucopyranoside
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- Compositae
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. [Content Brief]

[2]. Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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