2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. (-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside  (Synonyms: (-)-Pinoresinol 4-O-β-D-glucopyranoside)

製品番号: HY-N0946 純度: 98.0%
COA 取扱説明書 Technical Support

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease.

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(-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside 構造式

CAS 番号 : 41607-20-9

容量 価格（税別） 在庫状況 数量
1 mg $400 在庫あり
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10 mg   お問い合わせ  
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(-)-Pinoresinol 4-O-glucoside 関連抗体

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製品説明

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

IC50 & Target

IC50: 48.13 µM (α-Glucosidase)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
>30 μM
Compound: 9
Anticancer activity against human A549 cells by SRB assay
Anticancer activity against human A549 cells by SRB assay
[PMID: 21420296]
BV-2 IC50
144.33 μM
Compound: 9
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of lipopolysaccharide induced NO production
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of lipopolysaccharide induced NO production
[PMID: 21420296]
N9 IC50
>100 μM
Compound: 20
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 28073678]
RAW264.7 IC50
>0.3 mM
Compound: 19
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
[PMID: 18986199]
RAW264.7 IC50
>0.3 μM/mL
Compound: 19
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs
[PMID: 18986199]
SK-MEL-2 IC50
>30 μM
Compound: 9
Anticancer activity against human SK-MEL-2 cells by SRB assay
Anticancer activity against human SK-MEL-2 cells by SRB assay
[PMID: 21420296]
SK-OV-3 IC50
>30 μM
Compound: 9
Anticancer activity against human SKOV3 cells by SRB assay
Anticancer activity against human SKOV3 cells by SRB assay
[PMID: 21420296]
XF498 IC50
25.37 μM
Compound: 9
Anticancer activity against human XF498 cells by SRB assay
Anticancer activity against human XF498 cells by SRB assay
[PMID: 21420296]
体外実験

(-)-Pinoresinol 4-O-glucoside (0, 10, 30 µM; 24 h) increases cell migration during the differentiation of pre-osteoblasts in osteogenic supplement medium (OS) containing 50 μg/mL[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 7 days) increases the early differentiation and increases mineralized nodule formation during differentiation of pre-Osteoblasts[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases the expressio of BMP2, ALP, OCN mRNA levels in pre-osteoblasts[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases protein level of BMP2, p-Smad1/5/8, RUNX2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Pinoresinol 4-O-glucoside 関連抗体

RT-PCR[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Upregulated the mRNA level of BMP2 and its target osteoblast genes, ALP and osteocalcin (OCN).

Western Blot Analysis[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Enhanced protein level of BMP2, followed by the phosphorylation of Smad1/5/8 and the expression of RUNX2.
体内実験

(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 27-30 g, Male Swiss albino mice[2]
Dosage: 50 mg/kg
Administration: P.o.; twenty days
Result: Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.
分子量

520.53

分子式

C26H32O11
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C([C@@H]3OC[C@]4([H])[C@@]3([H])CO[C@H]4C5=CC=C(O)C(OC)=C5)C=C2OC
Structure Classification
Initial Source
輸送条件

Shipping with dry ice.
保管条件

-80°C, sealed storage, away from moisture and light
純度とドキュメンテーション
参考文献
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(-)-Pinoresinol 4-O-glucoside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Pinoresinol 4-O-glucoside41607-20-9(-)-Pinoresinol 4-O-β-D-glucopyranosideGlycosidasepre-osteoblastsmigrationoxidative stresshyperglycemiahepatic toxicityosteoporosisInhibitorinhibitorinhibit

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製品名:
(-)-Pinoresinol 4-O-glucoside
製品番号:
HY-N0946
数量:
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