2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. (-)-Pinoresinol 4-O-glucoside

(-)-Pinoresinol 4-O-glucoside  (Synonyms: (-)-Pinoresinol 4-O-β-D-glucopyranoside)

Cat. No.: HY-N0946
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(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease.

For research use only. We do not sell to patients.

(-)-Pinoresinol 4-O-glucoside Chemical Structure

(-)-Pinoresinol 4-O-glucoside Chemical Structure

CAS No. : 41607-20-9

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(-)-Pinoresinol 4-O-glucoside Related Antibodies

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Description

(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

IC50 & Target

IC50: 48.13 µM (α-Glucosidase)[1]
In Vitro

(-)-Pinoresinol 4-O-glucoside (0, 10, 30 µM; 24 h) increases cell migration during the differentiation of pre-osteoblasts in osteogenic supplement medium (OS) containing 50 μg/mL[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 7 days) increases the early differentiation and increases mineralized nodule formation during differentiation of pre-Osteoblasts[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases the expressio of BMP2, ALP, OCN mRNA levels in pre-osteoblasts[1].
(-)-Pinoresinol 4-O-glucoside (10, 30 µM; 3 days) increases protein level of BMP2, p-Smad1/5/8, RUNX2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Pinoresinol 4-O-glucoside Related Antibodies

RT-PCR[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Upregulated the mRNA level of BMP2 and its target osteoblast genes, ALP and osteocalcin (OCN).

Western Blot Analysis[1]

Cell Line: pre-osteoblasts
Concentration: 10, 30 µM
Incubation Time: 3 days
Result: Enhanced protein level of BMP2, followed by the phosphorylation of Smad1/5/8 and the expression of RUNX2.
In Vivo

(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 27-30 g, Male Swiss albino mice[2]
Dosage: 50 mg/kg
Administration: P.o.; twenty days
Result: Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%.
Molecular Weight

520.53

Formula

C26H32O11
CAS No.
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C([C@@H]3OC[C@]4([H])[C@@]3([H])CO[C@H]4C5=CC=C(O)C(OC)=C5)C=C2OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)-Pinoresinol 4-O-glucoside Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Pinoresinol 4-O-glucoside41607-20-9(-)-Pinoresinol 4-O-β-D-glucopyranosideGlucosidasepre-osteoblastsmigrationoxidative stresshyperglycemiahepatic toxicityosteoporosisInhibitorinhibitorinhibit

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