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Results for "

(S)-isomer

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (3) Adrenergic Receptor (3) AMPK (1) Androgen Receptor (1) Apoptosis (1) Arrestin (1) ATM/ATR (1) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (6) Calcium Channel (5) CCR (1) CDK (1) Dopamine Receptor (1) Drug Intermediate (2) Drug Isomer (13) Elastase (1) Endogenous Metabolite (4) HDAC (1) HMG-CoA Reductase (HMGCR) (2) HSV (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (2) LPL Receptor (1) Monoamine Oxidase (1) P-glycoprotein (1) Phosphodiesterase (PDE) (3) Prostaglandin Receptor (2) PSMA (1) Reference Standards (1) RSV (1) Sodium Channel (3) Thyroid Hormone Receptor (2) TRP Channel (1)
研究分野別:	Cancer (19) Cardiovascular Disease (9) Endocrinology (2) Infection (4) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (11)
Oligonucleotides:	Cationic Lipids (1)

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製品番号	製品名	Target	研究分野	構造式

HY-113380

(S)-β-Aminoisobutyric acid 1 Publications Verification	Endogenous Metabolite Drug Isomer Apoptosis AMPK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
(S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise .

HY-15532B

*SCH900776 (S-isomer)* MK-8776 S-isomer	Drug Isomer	Cancer
SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC₅₀ of 3 nM.

HY-114271A

*T3-ATA (S-isomer)*	Thyroid Hormone Receptor	Endocrinology
T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.

HY-103641A

(2S)-Octyl-α-hydroxyglutarate 2 Publications Verification (2S)-Octyl-2-HG	Drug Isomer	Cancer
(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.

HY-75095

(S)-(-)-1-Phenylethanamine S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine	Drug Intermediate Biochemical Assay Reagents	Neurological Disease
(S)-(-)-1-Phenylethanamine (S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine) is a S-isomer of 1-Phenylethanamine (HY-W012848). (S)-(-)-1-Phenylethanamine can be used as a pharmaceutical intermediate for the synthesis of various active compounds .

HY-126068

Esamisulpride (S)-Amisulpride; (S)-Aramisulpride; (S)-DAN 2163	Dopamine Receptor 5-HT Receptor	Neurological Disease
Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine D₂/D₃ receptor antagonist with K_i values of 4.43 nM for D₂R and 0.72 nM for D₃R. Esamisulpride is a 5-HT₇ receptor antagonist with a K_i of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression .

HY-Y0982

(S)-BINAP	Biochemical Assay Reagents	Cancer
(S)-BINAP is the S-isomer of BINAP (HY-Y0003). BINAP is a chiral bisphosphine ligand. (S)-BINAP can be used to assist in the synthesis of compounds with anticancer activity .

HY-126028A

(+)-Sotalol (S)-Sotalol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle .

HY-111540B

(S)-LY-3381916 1 Publications Verification (S)-IDO1-IN-5	Indoleamine 2,3-Dioxygenase (IDO)	Cancer
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC₅₀ value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .

HY-W674436

(S)-Thalidomide-4-OH	Drug Isomer	Cancer
(S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .

HY-120039A

(S)-MDL-101146	Elastase	Inflammation/Immunology
(S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a K_i value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .

HY-162002A

(S)-WSD0628	ATM/ATR	Cancer
(S)-WSD0628 (Compound 28) is the S-isomer of WSD0628 (HY-162002). (S)-WSD0628 is the inhibitor for ATM that inhibits the phosphorylation of ATM in MCF-7 cell with IC₅₀ <100 nM. (S)-WSD0628 exhibits radiosensitizing activity. (S)-WSD0628 can cross blood-brain barrier .

HY-114272A

*T4-ATA (S-isomer)*	Thyroid Hormone Receptor	Endocrinology
T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.

HY-105084A

Lubeluzole dihydrochloride	Sodium Channel Calcium Channel	Cardiovascular Disease Infection Neurological Disease Cancer
Lubeluzole dihydrochloride is the dihydrochloride salt of Lubeluzole (HY-105084). Lubeluzole dihydrochloride is the S-isomer of benzothiazole derivative. Lubeluzole dihydrochloride can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole dihydrochloride exhibits anti-ischemic and neuroprotective effects. Lubeluzole dihydrochloride also shows anti-bacterial and anti-diarrheal potential. Lubeluzole dihydrochloride can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole dihydrochloride can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole dihydrochloride can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .

HY-112371

(S)-CR8	CDK	Cancer
(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC₅₀s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC₅₀ 0.40 μM) .

HY-W093104

(S)-(-)-2-Methylbutanol (S)-2-Methyl-1-butanol	Endogenous Metabolite	Others
(S)-(-)-2-Methylbutanol is a S-isomer of 2-Methylbutanol .

HY-19487A

Ribocil B Ribocil S enantiomer; ent-Ribocil A	Bacterial	Infection
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a K_D of 6.6 nM.

HY-103035

BIO-32546	Phosphodiesterase (PDE)	Cancer
BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1 .

HY-105084

Lubeluzole	Sodium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Cancer
Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .

HY-179783A

*18:0 Dibromo MG (S-isomer)*	Biochemical Assay Reagents	Metabolic Disease
18:0 Dibromo MG (S-isomer) acts as a detergent for crystallization.

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-168776

(S)-C12-200	Biochemical Assay Reagents	Others
(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .

HY-143921S

Almorexant (αS,1S) isomer-13C,d3	Isotope-Labeled Compounds	Others
Almorexant (αS,1S) isomer- ¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant (αS,1S) isomer .

HY-114552

(S)-Dabelotine	Adrenergic Receptor	Neurological Disease
(S)-Dabelotine is the S-isomer of Dabelotine and serves as an adrenergic agonist in the investigation of dementia.

HY-167168

(S)-Azelnidipine	Calcium Channel	Cardiovascular Disease
(S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research .

HY-112895A

(R)-UT-155	Androgen Receptor	Cancer
(R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer .

HY-12993A

RSV604 racemate A-60444 racemate	RSV	Others
RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.

HY-105109B

(S)-Cilansetron	5-HT Receptor	Neurological Disease
(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome .

HY-129436

(S)-Bucindolol	Adrenergic Receptor	Cardiovascular Disease
(S)-Bucindolol is the (S)-isomer of Bucindolol (HY-103214), a β₁-adrenergic receptor blocker. (S)-Bucindolol can be utilized in research on cardiac failure .

HY-163529A

(S)-HN0037	HSV	Infection
(S)-HN0037 is the (S)-isomer of HN0037 (HY-163529), a selective and orally active helicase-primase inhibitor that inhibits HSV replication by targeting the viral helicase-primase enzyme complex .

HY-114061

(R)-FTY 720P	LPL Receptor	Others
(R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P_1,3,4,5 than (S)-Isomer (HY-15382) .

HY-139124

15(R)-15-Methyl Prostaglandin F2α 15(R)-Carboprost; 15(R)-15-methyl PGF2α	Prostaglandin Receptor	Metabolic Disease
15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.

HY-103641AS1

(2R)-Octyl-α-hydroxyglutarate-d17 (2R)-Octyl-2-HG-d₁₇	Isotope-Labeled Compounds Others	Cancer
(2R)-Octyl-α-hydroxyglutarate-d₁₇ ((2R)-Octyl-2-HG-d₁₇) is deuterium labeled (2R)-Octyl-α-hydroxyglutarate (HY-103641). (2R)-Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate .

HY-14664F

(3R,5S)-Fluvastatin sodium (3R,5S)-XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy	Cancer
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-169780

(S)-AMG-628	TRP Channel	Neurological Disease Inflammation/Immunology
(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca ²⁺-influx with IC₅₀ of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models .

HY-162495A

(S)-IDOR-1117-2520	Drug Isomer CCR Calcium Channel Arrestin P-glycoprotein	Inflammation/Immunology
(S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520 (HY-162495). IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC₅₀ = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC₅₀ = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation .

HY-121535

Levosemotiadil	Sodium Channel Calcium Channel	Others
Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .

HY-113943

9(S)-HETE	Endogenous Metabolite	Others
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .

HY-101339A

(R)-RS 56812 hydrochloride	5-HT Receptor	Others
(R)-RS 56812 hydrochloride is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.

HY-101339

(R)-RS 56812	Others	Others
(R)-RS 56812 is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.

HY-117044A

(±)12-HEPE	Prostaglandin Receptor	Metabolic Disease
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

HY-N7801

(±)5-HEPE	Drug Isomer	Metabolic Disease
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

HY-Z19668

Edoxaban impurity 12 Edoxaban cyclohexane ethyl ester (S,S,S)-isomer	Drug Intermediate	Others
Edoxaban impurity 12 (Edoxaban cyclohexane ethyl ester (S,S,S)-isomer) is an impurity of Edoxaban.

HY-B0280A

(S)-Ranolazine (S)-CVT 303; (S)-RS 43285-003	Drug Isomer	Cardiovascular Disease
(S)-Ranolazine is the S-isomer of Ranolazine (HY-B0280). Ranolazine is an antianginal agent .

HY-E71119

(S)-Coclaurine-N-methyltransferase	Biochemical Assay Reagents	Others
(S)-Coclaurine-N-methyltransferase (EC 2.1.1.140) is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.

HY-172938

C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0)	Drug Isomer	Others
C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0) is the 2S-isomer of C24 Dihydro ceramide (d18:0/24:0) (HY-156206) and the S-isomer of C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0) (HY-158952).

HY-153130

(S)-Zadavotide guraxetan (S)-PSMA I&T; (S)-PNT-2002	Drug Isomer PSMA	Cancer
(S)-Zadavotide guraxetan ((S)-PSMA I&T) is the S-isomer of EuK-Sub-kf-iodo-y-DOTAGA. (S)-Zadavotide guraxetan is a PSMA targeting compound .

HY-156438A

(S)-Ruvonoflast (S)-NT-0796	Drug Isomer	Neurological Disease
(S)-Ruvonoflast ((S)-NT-0796) is the S-isomer of Ruvonoflast (HY-156438). Ruvonoflast (NT-0796) is an orally active, selective, centrally nervous system-transporting NLRP3 inflammasome inhibitor .

HY-118572

(S)-Allantoin	Drug Isomer	Others
(S)-Allantoin is the S-isomer of Allantoin (HY-N0543). (S)-Allantoin binds selectively in the active site of urate oxidase. (S)-Allantoin can be converted to Allantoate by the action of allantoicase. (S)-Allantoin serves as a source of nitrogen in Arabidopsis thaliana .

HY-103035R

BIO-32546 (Standard)	Reference Standards Phosphodiesterase (PDE)	Cancer
BIO-32546 (Standard) is the analytical standard of BIO-32546 (HY-103035). This product is intended for research and analytical applications. BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1 .

製品番号	製品名	Category	Target	構造式

HY-113380

(S)-β-Aminoisobutyric acid 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Isomer Apoptosis AMPK
(S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise .

HY-118572

(S)-Allantoin	Structural Classification Caprifoliaceae Cordyceps bassiana Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Drug Isomer
(S)-Allantoin is the S-isomer of Allantoin (HY-N0543). (S)-Allantoin binds selectively in the active site of urate oxidase. (S)-Allantoin can be converted to Allantoate by the action of allantoicase. (S)-Allantoin serves as a source of nitrogen in Arabidopsis thaliana .

製品番号	製品名	構造式

HY-143921S

Almorexant (αS,1S) isomer-13C,d3
Almorexant (αS,1S) isomer- ¹³C,d₃ is the ¹³C- and deuterium labeled Almorexant (αS,1S) isomer .

HY-103641AS1

(2R)-Octyl-α-hydroxyglutarate-d17
(2R)-Octyl-α-hydroxyglutarate-d₁₇ ((2R)-Octyl-2-HG-d₁₇) is deuterium labeled (2R)-Octyl-α-hydroxyglutarate (HY-103641). (2R)-Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate .

製品番号	製品名		Classification

HY-168776

(S)-C12-200		Cationic Lipids
(S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .

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